EXOSC8
EXOSC8 is a protein in humans that is encoded by EXOSC8 gene. Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
EXOSC8 Antibodies
EXOSC8 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007896GA01HU | EXOSC8 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA853387LA01HU | EXOSC8 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA853387LB01HU | EXOSC8 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA853387LC01HU | EXOSC8 Antibody, FITC conjugated | Human | |
| CSB-PA853387LD01HU | EXOSC8 Antibody, Biotin conjugated | Human | ELISA |
EXOSC8 Proteins
EXOSC8 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP639739BO CSB-EP639739BO CSB-BP639739BO CSB-MP639739BO CSB-EP639739BO-B |
Recombinant Bovine Exosome complex component RRP43 (EXOSC8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC8 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP853387HU CSB-EP853387HU CSB-BP853387HU CSB-MP853387HU CSB-EP853387HU-B |
Recombinant Human Exosome complex component RRP43 (EXOSC8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC8 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP884014MO CSB-EP884014MO CSB-BP884014MO CSB-MP884014MO CSB-EP884014MO-B |
Recombinant Mouse Exosome complex component RRP43 (Exosc8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
