Recombinant Human Exosome complex component RRP43 (EXOSC8)

中文名稱：

人EXOSC8重組蛋白
貨號：

CSB-YP853387HU
規格：
來源：

Yeast
其他：

中文名稱：

人EXOSC8重組蛋白
貨號：

CSB-EP853387HU
規格：
來源：

E.coli
其他：

中文名稱：

人EXOSC8重組蛋白
貨號：

CSB-EP853387HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人EXOSC8重組蛋白
貨號：

CSB-BP853387HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人EXOSC8重組蛋白
貨號：

CSB-MP853387HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

EXOSC8
Uniprot No.：

Q96B26
別名：

bA421P11.3; CBP interacting protein 3; CIP3; EAP2; EC 3.1.13; EXOS8_HUMAN; EXOSC8; Exosome complex component RRP43; Exosome complex exonuclease RRP43; Exosome component 8; OIP-2; OIP2; Opa interacting protein 2 ; Opa-interacting protein 2; OTTHUMP00000042274; p9; Ribosomal RNA processing protein 43; Ribosomal RNA processing protein 43; S. cerevisiae; homolog of; Ribosomal RNA-processing protein 43; RP11 421P11.3 ; RRP43; Rrp43p
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-276
氨基酸序列

AAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTVNIG SISTADGSAL VKLGNTTVIC GVKAEFAAPS TDAPDKGYVV PNVDLPPLCS SRFRSGPPGE EAQVASQFIA DVIENSQIIQ KEDLCISPGK LVWVLYCDLI CLDYDGNILD ACTFALLAAL KNVQLPEVTI NEETALAEVN LKKKSYLNIR THPVATSFAV FDDTLLIVDP TGEEEHLATG TLTIVMDEEG KLCCLHKPGG SGLTGAKLQD CMSRAVTRHK EVKKLMDEVI KSMKPK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
基因功能參考文獻：
1. homozygous missense mutations cause progressive and lethal neurological disease PMID: 24989451
2. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. PMID: 12419256
相關疾病：

Pontocerebellar hypoplasia 1C (PCH1C)
亞細胞定位：

Cytoplasm. Nucleus. Nucleus, nucleolus.
蛋白家族：

RNase PH family
數據庫鏈接：

HGNC: 17035

OMIM: 606019

KEGG: hsa:11340

STRING: 9606.ENSP00000374354

UniGene: Hs.294041