EFNA1
EFNA1，全稱Ephrin-A1，也被稱為EPLG1、LERK1、TNFAIP4或B61，屬于Ephrin家族。該蛋白是一種細(xì)胞表面GPI結(jié)合配體，能與Eph受體相互作用，Eph受體是受體酪氨酸激酶家族成員，對神經(jīng)元、血管和上皮發(fā)育過程中的遷移、排斥和粘附至關(guān)重要。EFNA1通過混雜結(jié)合相鄰細(xì)胞上的Eph受體，引發(fā)接觸依賴的雙向信號傳導(dǎo)，參與血管生成和腫瘤新生血管形成。研究發(fā)現(xiàn)，EFNA1過表達(dá)與多種癌癥轉(zhuǎn)移相關(guān)，抑制其表達(dá)可減少腫瘤血管化，因此EFNA1/EphA2軸成為抗癌藥物開發(fā)的潛在靶點(diǎn)。目前，針對EFNA1的藥物研發(fā)主要集中在靶向其與Eph受體結(jié)合的抑制劑，以及通過調(diào)節(jié)EFNA1表達(dá)來干預(yù)腫瘤轉(zhuǎn)移和血管生成等病理過程。
熱銷產(chǎn)品
Recombinant Human Ephrin-A1 (EFNA1) (Active) (CSB-MP007460HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 (CSB-MP007722HUd7) at 2 μg/ml can bind Human EFNA1. The EC50 is 5.859-7.758 ng/mL.
EFNA1 Antibody (CSB-PA007460ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007460ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007460ESR1HU at dilution of 1:100
Human Ephrin-A1(EFNA1) ELISA kit (CSB-EL007460HU)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL007460HU
規(guī)格：96T/48T
靈敏度：0.039 ng/mL
檢測范圍：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
EFNA1 Antibodies
EFNA1 for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007460LA01RA | Efna1 Antibody | Rat | ELISA |
EFNA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA007460ESR1HU | EFNA1 Antibody | Human | ELISA, IHC |
| CSB-PA551061 | EFNA1 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA002367 | EFNA1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA256498 | EFNA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA999540 | EFNA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
EFNA1 Proteins
EFNA1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007460RA | Recombinant Rat Ephrin-A1 (Efna1) | Yeast |
| CSB-EP007460RAe0 | Recombinant Rat Ephrin-A1 (Efna1) | E.coli |
| CSB-EP007460RA | Recombinant Rat Ephrin-A1 (Efna1) | E.coli |
| CSB-BP007460RA CSB-MP007460RA CSB-EP007460RA-B |
Recombinant Rat Ephrin-A1 (Efna1) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EFNA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007460HU CSB-BP007460HU CSB-EP007460HU-B |
Recombinant Human Ephrin-A1 (EFNA1) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP007460HU | Recombinant Human Ephrin-A1 (EFNA1) | E.coli |
| CSB-AP005711HU | Recombinant Human Ephrin-A1 (EFNA1) (Active) | Mammalian cell |
| CSB-MP007460HU | Recombinant Human Ephrin-A1 (EFNA1) (Active) | Mammalian cell |
EFNA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007460MO CSB-EP007460MO CSB-BP007460MO CSB-MP007460MO CSB-EP007460MO-B |
Recombinant Mouse Ephrin-A1 (Efna1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005771MO | Recombinant Mouse Ephrin-A1 (Efna1), partial (Active) | Mammalian cell |
EFNA1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007460XBE CSB-EP007460XBE CSB-BP007460XBE CSB-MP007460XBE CSB-EP007460XBE-B |
Recombinant Xenopus laevis Ephrin-A1 (efna1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EFNA1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007460BO CSB-EP007460BO CSB-BP007460BO CSB-MP007460BO CSB-EP007460BO-B |
Recombinant Bovine Ephrin-A1 (EFNA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EFNA1 ELISA Kit
EFNA1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007460HU | Human Ephrin-A1(EFNA1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |
EFNA1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007460MO | Mouse Ephrin-A1(EFNA1) ELISA kit | serum, plasma, tissue homogenates | 23.43 pg/mL |
