CSF2RB (trabikibart Biosimilar) Recombinant Monoclonal Antibody
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貨號(hào)：CSB-RA006047MB2HU
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規(guī)格：
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Beta-C antibody; CD131 antibody; CDw131 antibody; Colony stimulating factor 2 receptor beta antibody; Colony stimulating factor 2 receptor beta low affinity；granulocyte macrophage antibody; Common beta chain antibody; Csf2rb antibody; Cytokine receptor common beta chain antibody; Cytokine receptor common beta chain precursor；CDw131 antigen antibody; Cytokine receptor common subunit beta antibody; GM CSF/IL 3/IL 5 receptor common beta chain antibody; GM-CSF/IL-3/IL-5 receptor common beta subunit antibody; granulocyte-macrophage colony-stimulating factor receptor, beta antibody; IL3RB antibody; IL3RB_HUMAN antibody; IL5RB antibody; Interleukin 3 receptor, beta antibody; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta；high affinity antibody; Interleukin 5 receptor, beta antibody; SMDP5 antibody; stimulating factor 3 receptor, beta；high affinity antibody
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反應(yīng)種屬：Human
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免疫原：Recombinant Human CSF2RB protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.88 -
產(chǎn)品提供形式：Liquid
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應(yīng)用說(shuō)明：Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：In stock
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用途：It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
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基因功能參考文獻(xiàn)：
- SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis. PMID: 28131718
- Exome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals. PMID: 27373512
- In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease. PMID: 27377463
- VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
- These data suggest that expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis PMID: 23108143
- JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling. PMID: 21965659
- Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells. PMID: 21176354
- Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils PMID: 20705940
- The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population. PMID: 21247258
- Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report] PMID: 21205713
- the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation. PMID: 21207215
- The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration. PMID: 20802515
- the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling PMID: 20516062
- Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms. PMID: 20472554
- hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex. PMID: 12384414
- JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR PMID: 12488507
- Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains PMID: 15060062
- A minor improvement in resolution has given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule. PMID: 16754968
- These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. PMID: 16767694
- This study found that several markers (rs2072707, rs2284031 and rs909486)of csf2rb showed sex-specific and family history-dependent associations with schizophrenia. PMID: 17667962
- The dynamic role of the common signaling subunit beta c is to prevent IL5alpha and GM-CSF ligand-receptor complexes from rapidly dissociating. PMID: 18294864
- The interaction between intercellular adhesion molecule 1 (ICAM-1) and the GM-CSF receptor is essential for GM-CSF-induced eosinophil activation and survival. PMID: 18322230
- IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
- Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit. PMID: 18374598
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相關(guān)疾病：Pulmonary surfactant metabolism dysfunction 5 (SMDP5)
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亞細(xì)胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Type I cytokine receptor family, Type 4 subfamily
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數(shù)據(jù)庫(kù)鏈接：
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