CCR8 (US11859000B2 Biosimilar) Recombinant Monoclonal Antibody

說明書

貨號：

CSB-RA004847MB4HU
規格：
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P51685
基因名：

CCR8
別名：

C C chemokine receptor type 8 antibody; C C CKR 8 antibody; C C motif chemokine receptor 8 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC chemokine receptor 8 antibody; CC chemokine receptor CHEMR1 antibody; CC chemokine receptor type 8 antibody; CC CKR 8 antibody; CC-CKR-8 antibody; CCR 8 antibody; CCR-8 antibody; Ccr8 antibody; CCR8 protein antibody; CCR8-L antibody; CCR8_HUMAN antibody; CDw198 antibody; CDw198 antigen antibody; Chemokine；C C motif receptor 8 antibody; Chemokine；C C receptor 8 antibody; Chemokine；C C receptor like 2 antibody; Chemokine；CC motif receptor 8 antibody; Chemokine；CC receptor 8 antibody; Chemokine；CC receptor like 1 antibody; Chemokine；CC receptor like 2 antibody; Chemokine C C motif receptor 8 antibody; Chemokine C C receptor 8 antibody; Chemokine CC motif receptor 8 antibody; Chemokine CC receptor 8 antibody; Chemokine receptor 8 antibody; Chemokine receptor like 1 antibody; Chemokine receptor-like 1 antibody; CKR L1 antibody; CKR-L1 antibody; CKRL 1 antibody; CKRL1 antibody; CMKBR 8 antibody; CMKBR L2 antibody; CMKBR8 antibody; CMKBRL 2 antibody; CMKBRL2 antibody; CY 6 antibody; CY6 antibody; GPR CY6 antibody; GPR-CY6 antibody; GPRCY6 antibody; MGC123958 antibody; MGC123959 antibody; MGC129966 antibody; MGC129973 antibody; TER 1 antibody; TER1 antibody
反應種屬：

Human
免疫原：

Recombinant Human CCR8 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.12
產品提供形式：

Liquid
應用說明：

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

In stock
用途：

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

功能：

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
基因功能參考文獻：
1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數據庫鏈接：

HGNC: 1609

OMIM: 601834

KEGG: hsa:1237

STRING: 9606.ENSP00000326432

UniGene: Hs.113222

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