Recombinant Bovine Type II iodothyronine deiodinase (DIO2)

in vitro E.coli expression system

中文名稱：

牛DIO2重組蛋白
貨號：

CSB-CF686311BO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

DIO2
Uniprot No.：

Q5I3B2
別名：

DIO2; Type II iodothyronine deiodinase; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達區域：

1-269
氨基酸序列

MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGM RCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASP ERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLFF EVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAY LGGKGPFFYNLQEVRRWLEKNFSKRUKLD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
基因功能參考文獻：
1. Increased expression of mammary TRbeta1 and DIO2, and decreased RXRalpha, provide a mechanism to increase thyroid hormone activity within the mammary gland during lactation. PMID: 18641053
亞細胞定位：

Membrane; Single-pass membrane protein.
蛋白家族：

Iodothyronine deiodinase family
組織特異性：

Highly expressed in thyroid, mammary and pituitary glands, then in hypothalamus. Low levels detected in diaphragm, heart, kidney and lung.
數據庫鏈接：

KEGG: bta:494548

STRING: 9913.ENSBTAP00000002107

UniGene: Bt.63066