Recombinant Rat Retinol-binding protein 4 (Rbp4)

中文名稱：

大鼠Rbp4重組蛋白
品名簡稱：

Recombinant Rat Rbp4 protein
貨號：

CSB-EP019483RA
說明書：

MSDS Datasheet
規格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Rbp4
Uniprot No.：

P04916
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

25.5 kDa
表達區域：

19-201aa
氨基酸序列

ERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGHMSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCADSYSFVFSRDPNGLTPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
基因功能參考文獻：
1. RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
2. plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
3. Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
4. Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
5. Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
6. RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
7. Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839
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亞細胞定位：

Secreted.
蛋白家族：

Calycin superfamily, Lipocalin family
組織特異性：

Detected in blood plasma (at protein level).
數據庫鏈接：

KEGG: rno:25703

STRING: 10116.ENSRNOP00000021055

UniGene: Rn.108214