Rat Retinol binding protein 4,RBP-4 ELISA Kit
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中文名稱：大鼠視黃醇結合蛋白4(RBP-4)酶聯免疫試劑盒
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貨號：CSB-E09424r
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規格：96T/48T
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價格：￥3900/￥2500
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其他：
產品詳情
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產品描述：大鼠視黃醇結合蛋白4(RBP-4)酶聯免疫試劑盒（CSB-E09424r）為競爭法ELISA試劑盒，定量檢測樣本中的RBP4含量。RBP4，全稱視黃醇結合蛋白4，是一種在血漿中運輸視黃醇的重要蛋白，由肝細胞合成，并在多種體液中分布。它在視黃醇的運輸和分布過程中發揮關鍵作用，與TTR和STRA6等蛋白相互作用，參與調節視黃醇的細胞膜運輸和防止腎小球濾過損失。RBP4的研究涉及其在代謝、心血管疾病和胰島素抵抗等病理過程中的作用機制。適用于代謝疾病機制研究、營養學實驗或藥物干預模型中RBP - 4動態變化的分析，為肥胖、糖尿病等科研領域提供可靠的數據支持，僅限科學研究使用。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Rbp4 ELISA Kit; Retinol-binding protein 4 ELISA Kit; Plasma retinol-binding protein ELISA Kit; PRBP ELISA Kit; RBP ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：
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檢測范圍：
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靈敏度：
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Signal Transduction
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測定原理：quantitative
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測定方法：Competitive
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數據處理：
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貨期：3-5 working days
引用文獻
- Augmentation of RBP4/STRA6 signaling leads to insulin resistance and inflammation and the plausible therapeutic role of vildagliptin and metformin K Gokulakrishnan,Molecular Biology Reports,2021
- The effect of moderate endurance training on gastrocnemius retinol-binding protein 4 and insulin resistance in streptozotocin-induced diabetic rats YousefiMohammad-Reza.et al,Interventional Medicine and Applied Science,2017
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靶點詳情
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最新研究進展：RBP4是一種在維生素A代謝中起關鍵作用的蛋白質，但它也與一些代謝性疾病如肥胖、糖尿病和代謝綜合征等有關。一些最新的研究表明，RBP4可能作為這些疾病的潛在生物標志物和治療靶點，有望為相關疾病的治療提供新的思路和策略。
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功能：Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
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基因功能參考文獻：
- RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
- plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
- Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
- Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
- Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
- RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
- Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839
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亞細胞定位：Secreted.
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蛋白家族：Calycin superfamily, Lipocalin family
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組織特異性：Detected in blood plasma (at protein level).
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數據庫鏈接：
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