Recombinant Rat Angiopoietin-1 (Angpt1)

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品名簡稱：

Recombinant Rat Angpt1 protein
貨號：

CSB-MP001706RAc7
說明書：

MSDS Datasheet
規格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Angpt1
Uniprot No.：

O35460
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
來源：

Mammalian cell
分子量：

56.5 kDa
表達區域：

20-497aa
氨基酸序列

SNQRRSPENGGRRYNRIQHGQCAYTFILPEHDGNCRESATEQYNTNALQRDAPHVETDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYELEKQLLQQTNEILKIQEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTFIIQELEKQLSRATSNNSVLQKQQLELMDTVHNLVSLCTKEVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNEGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNQKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
基因功能參考文獻：
1. Overexpression of Ang-1 enhanced the tube formation, migration, and proliferation ability of endothelial progenitor cells. EPC transplantation facilitated occlusion of carotid aneurysms. PMID: 29197611
2. The study showed for the first time that ANG-1 plays a vital role in the early rather than late phase of adjuvant-induced arthritis pathogenesis making it an attractive non-invasive tool for early diagnosis and prediction of disease prognosis PMID: 24664592
3. Ang-1-EPC improved cell survival during inflammation. PMID: 24606182
4. Ang1 was implicated in ASC-induced suppression of neointimal formation. PMID: 23486192
5. Endothelin-1 regulates ANG-1 production and vascular endothelial growth factor (VEGF)A in proliferating astrocytes. PMID: 22927341
6. responsible for the vascular hyperreactivity at early hemorrhagic shock through the Tie2-Akt-eNOS pathway PMID: 22869617
7. The expression of Ang-1 mRNA and TSP-1 in renal tissue of rats after subtotal nephrectomy was significantly up-regulated. PMID: 19821086
8. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation PMID: 22843181
9. Prolonged exposure of high concentration of oxygen may cause impairment of lung vascular development by inhibiting expression of Ang-1 in neonatal rats. PMID: 22336306
10. The change of Ang-1, which is early upregulation and late downregulation, exists in diabetic renal tissue. PMID: 17294737
11. Wenyang Huoxue Recipe can up-regulate the expression of Ang-l mRNA rats with chronic aristolochic acid nephropathy. PMID: 18471417
12. Expression of angiopoietin-1 and the angiopoietin receptor dropped markedly after stroke in SHR stroke-prone rats, but was not different after ischemia in SHR and WKY rat strains PMID: 11822892
13. ang 1 stabilizes testicular microvessels under basal conditions and that a shift in this balance caused by increased ang 2, together with increased VEGF-A, allows vascular leakage, high endothelial cell proliferation PMID: 12773423
14. Rats engineered to express angiopoietin 1 (Ang-1) constitutively in the lung develop severe pulmonary hypertension. PMID: 14512515
15. Overexpression of angiopoietin-1 using an adeno-associated virus vector causes pulmonary hypertension in rats. These data provide a novel physiologic animal model for pulmonary hypertension. PMID: 14759414
16. E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha, priming the middle cerebral artery territory for survival after experimental focal ischemia PMID: 15637314
17. Ang-1 promotes neurite outgrowth from dorsal root ganglia cells positive for Tie2. PMID: 15714275
18. It is concluded that adipocyte-secreted Ang-1 supports neurite outgrowth, which is involved in synaptogenesis. The novel function of Ang-1 appears to play a physiological role in WAT plasticity. PMID: 16493688
19. Ang1 protects cardiomyocytes from oxidative stress-induced apoptosis by regulating the activity of Proto-Oncogene Proteins c-akt PMID: 17559808
20. ANGPT1 is necessary for follicular development induced by gonadotropins. PMID: 17989359
21. Expression of angiopoietin-1 significantly decreased in the pulmonary arteries in chronic hypoxic pulmonary hypertension. PMID: 18073453
22. Abnormal expression and reciprocal egulation of Angpt1 may play important roles in the development of chronic allograft nephropathy in rat renal allografts. PMID: 18929864
23. Ang1 modifies basal microvessel permeability coefficients, in keeping with previous reports demonstrating reduced solute flux in inflamed vessels. PMID: 19297368
24. Ang1 induces neurite outgrowth in PC12 cells in a Tie2-independent, beta1-integrin-FAK-PI3K-Akt-dependent manner. NGF and Ang1 mediate neurite outgrowth via two independent signaling mechanisms. PMID: 19379779
25. Vascular endothelial growth factor and angiopoietin-1 are involved in liver regeneration following partial hepatectomy. PMID: 11549276
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亞細胞定位：

Secreted.
數據庫鏈接：

KEGG: rno:89807

STRING: 10116.ENSRNOP00000007979

UniGene: Rn.161953