Recombinant Mouse Zinc/RING finger protein 3 (Znrf3), partial

中文名稱：

小鼠Znrf3重組蛋白
貨號：

CSB-YP716332MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Znrf3重組蛋白
貨號：

CSB-EP716332MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Znrf3重組蛋白
貨號：

CSB-EP716332MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Znrf3重組蛋白
貨號：

CSB-BP716332MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Znrf3重組蛋白
貨號：

CSB-MP716332MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Znrf3
Uniprot No.：

Q5SSZ7
別名：

Znrf3; E3 ubiquitin-protein ligase ZNRF3; EC 2.3.2.27; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
基因功能參考文獻：
1. XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects. PMID: 29735715
2. Crystal structure confirming that Rspo proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex. PMID: 26123262
3. data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3 PMID: 22575959
亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

ZNRF3 family
數據庫鏈接：

KEGG: mmu:407821

STRING: 10090.ENSMUSP00000105493

UniGene: Mm.216313