ZNRF3
ZNRF3（Zinc and Ring Finger 3）屬于RING（Really Interesting New Gene）指環(huán)蛋白家族，它包含一個(gè)RING結(jié)構(gòu)域，這是一個(gè)特定類(lèi)型的結(jié)構(gòu)域，具有E3泛素連接酶活性。ZNRF3的主要功能之一是調(diào)節(jié)細(xì)胞膜上受體和蛋白質(zhì)的穩(wěn)定性。它通過(guò)將泛素分子附加到目標(biāo)蛋白質(zhì)上，標(biāo)記它們以進(jìn)行降解。這個(gè)過(guò)程被稱(chēng)為泛素化，是細(xì)胞對(duì)于調(diào)控蛋白質(zhì)水平和信號(hào)通路的重要機(jī)制之一。在癌癥研究領(lǐng)域，ZNRF3與Wnt信號(hào)通路的調(diào)控有關(guān)，該信號(hào)通路在多種癌癥中起關(guān)鍵作用。
熱銷(xiāo)產(chǎn)品
Recombinant Human E3 ubiquitin-protein ligase ZNRF3(ZNRF3),partial (Active) CSB-MP890933HU
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ZNRF3 at 5 μg/ml can bind Human RSPO2 (CSB-MP751021HU1(M)), the EC50 is 5.091-6.991 ng/mL.
ZNRF3 Antibodies
ZNRF3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA890933HA01HU | ZNRF3 Antibody | Human | ELISA, IF |
| CSB-PA890933HB01HU | ZNRF3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA890933HC01HU | ZNRF3 Antibody, FITC conjugated | Human | |
| CSB-PA890933HD01HU | ZNRF3 Antibody, Biotin conjugated | Human | ELISA |
ZNRF3 Proteins
ZNRF3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP716332MO CSB-EP716332MO CSB-BP716332MO CSB-MP716332MO CSB-EP716332MO-B |
Recombinant Mouse Zinc/RING finger protein 3 (Znrf3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ZNRF3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-EP890933HU-B |
Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial | In Vivo Biotinylation in E.coli |
| CSB-EP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial | E.coli |
| CSB-EP890933HUe1 | Recombinant Human Zinc/RING finger protein 3 (ZNRF3),Partial | E.coli |
| CSB-BP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial | Baculovirus |
| CSB-YP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial | Yeast |
| CSB-MP890933HU | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial (Active) | Mammalian cell |
