Recombinant Mouse Serotransferrin (Tf)

中文名稱：

小鼠Tf重組蛋白
貨號：

CSB-YP856363MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tf重組蛋白
貨號：

CSB-EP856363MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tf重組蛋白
貨號：

CSB-EP856363MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tf重組蛋白
貨號：

CSB-BP856363MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tf重組蛋白
貨號：

CSB-MP856363MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tf
Uniprot No.：

Q921I1
別名：

Tf; Trf; Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-697
氨基酸序列

V PDKTVKWCAV SEHENTKCIS FRDHMKTVLP PDGPRLACVK KTSYPDCIKA ISASEADAMT LDGGWVYDAG LTPNNLKPVA AEFYGSVEHP QTYYYAVAVV KKGTDFQLNQ LEGKKSCHTG LGRSAGWVIP IGLLFCKLSE PRSPLEKAVS SFFSGSCVPC ADPVAFPKLC QLCPGCGCSS TQPFFGYVGA FKCLKDGGGD VAFVKHTTIF EVLPEKADRD QYELLCLDNT RKPVDQYEDC YLARIPSHAV VARKNNGKED LIWEILKVAQ EHFGKGKSKD FQLFSSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHNYVT AIRNQQEGVC PEGSIDNSPV KWCALSHLER TKCDEWSIIS EGKIECESAE TTEDCIEKIV NGEADAMTLD GGHAYIAGQC GLVPVMAEYY ESSNCAIPSQ QGIFPKGYYA VAVVKASDTS ITWNNLKGKK SCHTGVDRTA GWNIPMGMLY NRINHCKFDE FFSQGCAPGY EKNSTLCDLC IGPLKCAPNN KEEYNGYTGA FRCLVEKGDV AFVKHQTVLD NTEGKNPAEW AKNLKQEDFE LLCPDGTRKP VKDFASCHLA QAPNHVVVSR KEKAARVKAV LTSQETLFGG SDCTGNFCLF KSTTKDLLFR DDTKCFVKLP EGTTPEKYLG AEYMQSVGNM RKCSTSRLLE ACTFHKH
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
基因功能參考文獻：
1. the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells. PMID: 27100851
2. Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38. PMID: 26639305
3. Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. PMID: 23650374
4. Together, these data indicate that Lcn2, in combination with transferrin, confines Klebsiella pneumoniae to the airways and prevents invasion into tissue containing the pulmonary vasculature. PMID: 23169997
5. Transferrin(hpx/hpx) Hemojuvelin(+/+) and Transferrin(hpx/hpx) Hemojuvelin(-/-) phenotypes did not differ markedly, but RBC transfusions increased hepcidin levels in Transferrin(hpx/hpx) Hemojuvelin(+/+) but not Transferrin(hpx/hpx) Hemojuvelin(-/-)mice. PMID: 21993681
6. These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice. PMID: 22363754
7. Neurodegenerative conditions involving iron-mediated toxicity may be due to a failure of iron transport or storage mechanisms, rather than to the presence of high levels of non-transferrin-bound iron. PMID: 20431983
8. Apotransferrin mitigates the neurotoxicity of hemoglobin in a cell culture model of intracerebral hemorrhage. PMID: 21034753
9. Descibed is the 2.4 A structure of inhibitor of carbonic anhydrase from a pseudomerohedral twinned crystal: a member of the transferrin superfamily. PMID: 20572014
10. transferrin receptor 2 and HFE are involved in holotransferrin-dependent signaling for the regulation of furin which involved Erk phosphorylation. Furin in turn may control hepcidin expression. PMID: 20634490
11. hepcidin expression in hypotransferrinemic mice is regulated both by transferrin-restricted erythropoiesis and by transferrin through a mechanism independent of its role in erythropoiesis PMID: 20956801
12. These data show that mycobacteria reside in the Rab11(+) endocytic recycling pathway, thereby retaining access to metabolizing transferrin and avoiding endocytosed immunoproteins like Lcn2. PMID: 20121435
13. during later times postinfection (1.5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome PMID: 16611921
14. Transsferrin overexpression has negative effects on testicular function and that transfserrin levels require strict regulation in the testis. PMID: 16998850
15. developing erythroid cells, which are taking up vast amounts of Fe, deliver the metal directly from transferrin-containing endosomes to mitochondria PMID: 17376890
16. The role of transferrin in glial protection was investigated. PMID: 18509548
17. Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery. PMID: 19154717
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亞細胞定位：

Secreted.
蛋白家族：

Transferrin family
組織特異性：

Expressed by the liver and secreted in plasma.
數據庫鏈接：

KEGG: mmu:22041

STRING: 10090.ENSMUSP00000035158

UniGene: Mm.37214