Recombinant Mouse SLIT-ROBO Rho GTPase-activating protein 3 (Srgap3), partial

中文名稱：

小鼠Srgap3重組蛋白
貨號：

CSB-YP772195MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Srgap3重組蛋白
貨號：

CSB-EP772195MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Srgap3重組蛋白
貨號：

CSB-EP772195MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Srgap3重組蛋白
貨號：

CSB-BP772195MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Srgap3重組蛋白
貨號：

CSB-MP772195MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Srgap3
Uniprot No.：

Q812A2
別名：

Srgap3; Arhgap14; Kiaa0411; Srgap2; SLIT-ROBO Rho GTPase-activating protein 3; srGAP3; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein; WRP
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
基因功能參考文獻：
1. SrGAP3 plays a role in neurodevelopmental disorders. PMID: 27184948
2. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice. PMID: 26104135
3. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins. PMID: 23127797
4. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. PMID: 23505444
5. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus PMID: 23007397
6. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders. PMID: 22820399
7. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14. PMID: 22271578
8. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1. PMID: 22159416
9. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus. PMID: 21655271
10. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner. PMID: 21350945
11. Results from these studies confirm that loss of WRP is linked to impaired learning and memory. PMID: 21325512
12. Both Slit and Netrin-1 contribute to floor plate-derived chemorepulsion of cranial motor axons. PMID: 20569485
13. WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. PMID: 17215396
14. Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. PMID: 18617019
15. Data show that compared to srGAP2 and srGAP3, the onset of srGAP1 expression is later in most CNS tissues in mouse. PMID: 19137586
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數據庫鏈接：

KEGG: mmu:259302

STRING: 10090.ENSMUSP00000085712

UniGene: Mm.236401