Recombinant Mouse Nuclear factor of activated T-cells, cytoplasmic 4 (Nfatc4), partial

中文名稱：

小鼠Nfatc4重組蛋白
貨號(hào)：

CSB-YP818323MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Nfatc4重組蛋白
貨號(hào)：

CSB-EP818323MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Nfatc4重組蛋白
貨號(hào)：

CSB-EP818323MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Nfatc4重組蛋白
貨號(hào)：

CSB-BP818323MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Nfatc4重組蛋白
貨號(hào)：

CSB-MP818323MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nfatc4
Uniprot No.：

Q8K120
別名：

Nfatc4; Nfat3; Nuclear factor of activated T-cells; cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter. Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription. Binds to and transactivates AGTR2 gene promoter. Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation. In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival. Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes. Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity. Binds to PPARG and REG3G gene promoters.
基因功能參考文獻(xiàn)：
1. Nfatc4 expression was coordinately upregulated by top hypoxia-activated transcription factors, while NFATc4 target genes were enriched in hypoxic neural stem cells. PMID: 26235896
2. results indicate that NFAT is a BACE1 transcription factor. Our study suggests that inhibition of NFAT-mediated BACE1 expression may be a valuable drug target for AD therapy PMID: 25663301
3. our results suggest that activation of NHE1 induces hypertrophy through the activation of NFAT3/Gata4 and OPN expression PMID: 25758355
4. Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice PMID: 25918731
5. L-carnitine reversed the activation of NFAT3 and PPARa caused by carboplatin through altering the phosphorylation of PTEN and AMPK. PMID: 25090113
6. Disrupting the calcineurin-NFAT axis by either genetic or pharmacologic approaches confers resistance to the development of social stress-induced voiding and dysfunction. PMID: 24909609
7. The NFATc4-dependent increase in hippocampal neurogenesis after GABAA receptor stimulation is required for suppression of anxiety response. PMID: 24948817
8. IL-13 specifically induced NFAT3 activation through promoting its dephosphorylation in air-liquid interface cultures of tracheal epithelial cells (mTECs). PMID: 24583134
9. Data suggest that expression of Itpr1 (inositol 1,4,5-triphosphate receptor 1) in cerebral cortex neurons is regulated by dopamine D2 receptors; Itpr1 is up-regulated via increased binding of NFATc4 and transcription factor AP-1 to Itpr1 promoter. PMID: 23597509
10. these results reveal a novel PI3K-independent role for p85alpha in controlling VEGF induction during the cellular UVB response by regulating NFAT3 activity. PMID: 23390317
11. Over-expression of NFATc4 up-regulated collagen III, MRTF-A (a transcriptional regulator of SMA) and the NFAT-target regulator of calcineurin 1.4. PMID: 23178899
12. As maturing cerebellar granule neurons become more hyperpolarized, NFATc4 binding declines leading to onset of nuclear factor one temporal binding and the NFI switch program PMID: 23407945
13. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway PMID: 22164265
14. Data observed a significant upregulation and phosphorylation of ZAP-70, protein kinase C theta;, nuclear factor of activated T cells, and glycogen synthase kinase 3beta in Tregs prepared from injury-site-draining lymph nodes. PMID: 20720513
15. The functional interaction between lipin 1 and the nuclear factor of activated T cells c4 (NFATc4), is described. PMID: 20385772
16. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. PMID: 11997522
17. NFATc4 is not regulated by calcineurin and is not essential for hypertrophic growth PMID: 12370307
18. Identification of a noncoding RNA repressor of the nuclear factor of activated T cells (NFAT) activity. PMID: 16141075
19. NFATc4 was expressed broadly, but not uniformly, throughout various brain structures. The highest levels of NFATc4 expression were localized to the hippocampus, olfactory bulb, and various hypothalamic nuclei. PMID: 16273547
20. These results demonstrate that the inducible NFAT3-mediated iNOS upregulation represents a novel potent tumor-suppressing pathway and may contribute to the tumor suppressor functions of NFAT protein. PMID: 16475165
21. This study demonstrates that silica was able to activate NFAT3 in an oxygen radical-dependent manner, which was required for TNF-alpha induction. PMID: 16489119
22. NFATc4 and ATF3 function as negative regulators of adiponectin gene expression in 3T3 adipocytes. PMID: 16644691
23. The data presented here demonstrated that NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation, indicating that the role of NFAT3 in regulating cell transformation is carcinogen-specific. PMID: 16718377
24. These findings suggest that NFAT3/cyclooxygenase-2 act as a link between inflammation and carcinogenesis by being involved in the tumor promotion stage. PMID: 16803872
25. establish a role for NFAT in glucose/insulin homeostasis and expand the repertoire of NFAT function to metabolic pathogenesis and adipokine gene transcription PMID: 16908540
26. RSK2 is an important kinase for NFAT3 in mediating myotube differentiation PMID: 17213202
27. A novel p85alpha/NFAT3/TNF-alpha signaling pathway for the mediation of cellular apoptotic responses under certain stress conditions such as UVR is identified PMID: 17242187
28. important role of NFAT3 activation in Benzo[a]pyrene diol-epoxide-induced cell transformation by up-regulation of TNF expression in mouse epidermal Cl41 cells. PMID: 17522069
29. deletion or mutation of the NFATc4 core DNA-binding site reverses IL-18 suppression of adiponectin promoter-reporter activity PMID: 18086672
30. Kinetic analyses demonstrate that rephosphorylation of Ser(168,170) of endogenous NFATc4 is mediated by mTOR and, surprisingly, by extracellular signal-regulated kinase 5 (ERK5) mitogen-activated protein kinase as well. PMID: 18347059
31. These data suggest that NFAT-mediated gene expression plays a role in deafferentation-induced apoptosis of cochlear nucleus neurons during a developmental critical period. PMID: 18354019
32. NFAT molecules are novel physiological targets for IRAK-1. PMID: 18691762
33. studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells PMID: 19179536
34. NFAT-3 has a role as a direct transcriptional repressor of GAP-43 expression PMID: 19443652
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亞細(xì)胞定位：

Cytoplasm. Nucleus.
組織特異性：

Widely expressed. In the brain, expressed in neurons. Expressed in the hippocampus (at protein level). In the hippocampus, expressed in both the CA1-CA3 pyramidal cells and the dentate gyrus granular cells. Expressed in a subset of hippocampal cells repre
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:73181

STRING: 10090.ENSMUSP00000024179

UniGene: Mm.27908