Recombinant Mouse Complement C1q subcomponent subunit A (C1qa)

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中文名稱：

Recombinant Mouse Complement C1q subcomponent subunit A(C1qa)
品名簡稱：

Recombinant Mouse C1qa protein
貨號：

CSB-YP003637MO
說明書：

MSDS Datasheet
規格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

C1qa
Uniprot No.：

P98086
別名：

C1qaComplement C1q subcomponent subunit A
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

Yeast
分子量：

25.6kDa
表達區域：

23-245aa
氨基酸序列

EDVCRAPNGKDGAPGNPGRPGRPGLKGERGEPGAAGIRTGIRGFKGDPGESGPPGKPGNVGLPGPSGPLGDSGPQGLKGVKGNPGNIRDQPRPAFSAIRQNPMTLGNVVIFDKVLTNQESPYQNHTGRFICAVPGFYYFNFQVISKWDLCLFIKSSSGGQPRDSLSFSNTNNKGLFQVLAGGTVLQLRRGDEVWIEKDPAKGRIYQGTEADSIFSGFLIFPSA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
基因功能參考文獻：
1. C1qa(-/-) mice did not show any differences in photoreceptor loss or inflammation at 7 days compared to wild-type PMID: 30126455
2. The results presented here demonstrate that the C1q expression in aged females experience a distinct difference in brain aging when compared to age-matched males, suggesting females undergo a higher level of microglial activation with age. PMID: 28732515
3. this study shows that regulatory dendritic cells can mediate a potent direct anti-inflammatory activity via the expression and/or secretion of molecules such as C1q, independently of their capacity to expand the pool of regulatory T cells PMID: 27731323
4. Data preliminarily suggest that complement C1q activity may aid in the clearance of the Toxoplasma gondii parasite from the central nervous system and in so doing, have consequences for the connectivity of neighboring cells and synapses PMID: 27109609
5. analysis of molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins modulated by complement protein C1q PMID: 27573737
6. C1q-/- mice manifest increased frequency of fetal resorption, reduced fetal weight, and smaller litter size when compared to their wild-type counterparts PMID: 27687635
7. This study demonstrated that microglia, but not neurons or peripheral sources, are the dominant source of C1q in the brain. PMID: 28264694
8. findings show that C1q rather than FcgammaRs controls the Ab-mediated Ag uptake and its presentation by spleen APC subsets to T cells PMID: 28432146
9. Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45-positive cells in kidney fibrosis. PMID: 28052876
10. Deleting C1qa gene significantly reduces synaptic pruning by Grn(-/-) microglia and mitigates neurodegeneration, behavioral phenotypes, and premature mortality in Grn(-/-) mice; results uncover a previously unrecognized role of progranulin in suppressing aberrant microglia activation during aging. PMID: 27114033
11. C1q level may be a surrogate of prediction marker representing neurodegenerative disease progress before developing behavioral impairment. PMID: 26728245
12. developmental mechanisms of C1qa may be re-engaged during injury response PMID: 27008854
13. that inhibition of C1 is sufficient to preserve dendritic and synaptic architecture PMID: 27048300
14. These findings support a role for locally synthesized C1q in promoting tumor growth. PMID: 26831747
15. C1q is involved in the pristane-mediated enhanced inflammatory response to TLR7 stimulation. PMID: 26773156
16. C1q has a role in pulmonary vascular homeostasis and preventing injury to lung endothelium PMID: 26487714
17. Data (including data from studies in mutant mice) suggest exercise prevents age-related neurovascular decline, up-regulation of C1qa, and down-regulation of astrocytic Apoe; this preventive effect of exercise does not occur in Apoe-deficient mice. PMID: 26512759
18. critical role in activation of beta-catenin signalling in hypertensive arterial remodelling PMID: 25716000
19. G allele in rs172378 risk factor for lupus nephritis in a homozygous status PMID: 25326229
20. Data (including data on knockout mice) suggest, in absence of Trem2 (triggering receptor expressed on myeloid cells 2), pulmonary macrophages selectively produce elevated levels of C1q resulting in enhanced phagocytosis during pneumococcal pneumonia. PMID: 24945405
21. Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins PMID: 25091012
22. C1q was significantly reduced in newly diagnosed schizophrenic patients or schizophrenic patients on medication compared with the controls. PMID: 23235303
23. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. PMID: 24170856
24. The structural abnormalities, together with increased numbers of excitatory synapses, likely contribute to epileptogenesis in C1q KO mice. PMID: 23621154
25. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity PMID: 23150673
26. These findings suggest that C1q recognizes an alternative binding partner expressed by stressed retinal ganglion cells. PMID: 22918632
27. Findings suggest the unexpected role of complement C1q in Wnt signal transduction and modulation of mammalian aging. PMID: 22682250
28. Our data indicate that C1q could have a role in regulating platelet activation and associated leukocyte recruitment during vessel wall injury. PMID: 22142906
29. Levels of C1q rise substantially in retinal tissues over the course of degeneration. in the absence of C1q, cone photoreceptor function and viability are significantly compromised. PMID: 21863053
30. analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages PMID: 21862594
31. Leukocyte recruitment and C1q-hemolytic activity was restored to wild type levels when CD93 was expressed on either hematopoietic cells or nonhematopoietic cells in bone marrow chimeric mice PMID: 21849679
32. C1q, a marker of microglial activation, is upregulated in the nigrostriatal system following subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); nigrostriatal dopaminergic injury is not affected by C1q in this model of Parkinson disease. PMID: 21640391
33. Mice with a mutation in complement component 1a (C1qa) were protected from glaucoma. PMID: 21383504
34. Complement 1q (C1q)-deficient mice lacking the classical complement pathway show significantly reduced survival and increased organ dysfunction, following cecal ligation and puncture when compared with control mice. PMID: 21263075
35. C1q directly promotes neuronal survival, thereby demonstrating new interactions between immune proteins and neuronal cells that may facilitate neuroprotection. PMID: 21368058
36. Ethanol activates the classical complement pathway via C1q binding to apoptotic cells in the liver and that C1q contributes to the pathogenesis of ethanol-induced liver injury. PMID: 20416309
37. Complement protein C1q forms a complex with cytotoxic prion protein oligomers PMID: 20410306
38. These results suggest that C1q and C3 facilitate the induction of intranasal tolerance. PMID: 20213737
39. Bacterial titers of both Streptococcus pneumoniae serotype 6A and 14 in the middle ear lavage fluid samples from Bf/C2(-/)(-), Bf(-)(/)(-), and C1qa(-/)(-) mice were significantly higher than in samples from wild-type mice. PMID: 20065024
40. C1q contributes to apoptotic cell clearance in vitro, but its genetic deletion has no effect on pulmonary apoptotic cell clearance in vivo. PMID: 12244199
41. Elevated expression of splenic prion protein (PrP) may be dependent on C1q, since PrP up-regulation does not occur in spleens of C1q-deficient mice following treatment with preformed immune complexes or vesicular stomatitis virus. PMID: 12794132
42. Evaluation using C1q-deficient mice shows that lung injury following gastrointestinal ischemia-reperfusion injury is independent of C1q and classical complement activation. PMID: 15879138
43. alpha2beta1 integrin is a novel receptor for multiple collectins and the C1q complement protein PMID: 16166590
44. The transmembrane lectin SIGN-R1 therefore contributes to innate resistance by an unusual C3 activation pathway. PMID: 16615889
45. bacterial titers in the CNS were almost 12- and 20-fold higher in C1q- and C3-deficient-mice, respectively. Mean CSF leukocyte counts were reduced by 47 and 73% in C1q- and C3-deficient-mice, respectively PMID: 17237437
46. The in vitro binding and activation of the human and mouse complement systems was analysed and the susceptibility to infection in complement-deficient mouse strains, was tested. PMID: 18501966
47. C1q participates in scrapie prion protein PrP(Sc) uptake by conventional dendritic cells (cDCs), revealing a critical role for cDCs in initial prion capture, an event that takes place before the PrP(Sc) accumulation within the follicular DC network. PMID: 19155476
48. IgM antibodies play a central role in protection against atherosclerosis; the mechanism appears to be at least partly independent of classical pathway complement activation by C1q PMID: 19620499
49. ARRB2 acts to limit JNK/ERK activation and survival in macrophages. PMID: 19783052
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亞細胞定位：

Secreted.
數據庫鏈接：

KEGG: mmu:12259

STRING: 10090.ENSMUSP00000048836

UniGene: Mm.439957