Recombinant Mouse Beta-defensin 2 (Defb2)

中文名稱：

Recombinant Mouse Beta-defensin 2(Defb2)
貨號：

CSB-YP006705MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Beta-defensin 2(Defb2)
貨號：

CSB-EP006705MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Beta-defensin 2(Defb2)
貨號：

CSB-EP006705MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Beta-defensin 2(Defb2)
貨號：

CSB-BP006705MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Beta-defensin 2(Defb2)
貨號：

CSB-MP006705MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Defb2
Uniprot No.：

P82020
別名：

Defb2Beta-defensin 2; BD-2; mBD-2; Defensin; beta 2
種屬：

Mus musculus (Mouse)
蛋白長度：

Cytoplasmic domain
表達區域：

21-71
氨基酸序列

AVGSLKSIGY EAELDHCHTN GGYCVRAICP PSARRPGSCF PEKNPCCKYM K
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Has bactericidal activity.
基因功能參考文獻：
1. Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease. PMID: 28622393
2. NOD2-mediated beta-defensin 2 regulation contributes to the protection against NTHi-induced otitis media PMID: 24625812
3. mouse urothelium produces mBD2 in response to intravesicular BCG as a defense mechanism against BCG PMID: 25573055
4. studied the time course of TLR9 and BD-2gene expression by the corneal epithelial cells in herpetic keratitis in C57Bl/6 and BALB/c mice PMID: 22816092
5. mBD-2 was located in cells with dendritic morphology near mediastinal lymph nodes. mBD-2 may play a role in the control of bacilli growth by contributing to establish a Th1 response, being a link between innate and adaptative immunity. PMID: 22705089
6. a highly size-specific, TLR4-dependent, innate defense response to fragmented HA contributes to intestinal epithelium barrier defense through the induction of intracellular HbetaD2 protein. PMID: 22761444
7. Expression and inducibility of mouse beta-defensins-2 was tested in a mouse ocular surface scratch model with and without treatment of supernatants of a clinical Staphylococcus aureus isolate by means of immunohistochemistry. PMID: 20526610
8. Murine beta-defensins BD2 and BD3 together promote resistance against corneal infection by Pseudomonas aeruginosa. PMID: 19933858
9. acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4, inducing up-regulation of costimulatory molecules and dendritic cell maturation PMID: 12411706
10. The results indicate that BD-2 and -3 may be upregulated during the development of autoimmune sialoadenitis. PMID: 17874048
11. Murine beta-defensin 2 (mDF2beta) can act as an endogenous ligand for TLR-4-activating maturation of dendritic cells. PMID: 18192488
12. pleural mesothelial cells may contribute to host innate immune defense upon exposure to gram-positive bacteria or their products within the pleural space by upregulating TLR-2 and beta-defensin-2 expression PMID: 18621910
13. defensin beta 2 production is mediated by TLR2 and TLR4 activation and involves a c-Fos-mediated, protein kinase C-dependent signaling pathway PMID: 18641349
14. The expression of BD2 was significantly elevated in the lungs of cigarette smoke-exposed mice compared with air-exposed mice. PMID: 18699806
15. Down regulation of beta-defensin-2 is associated with aggressive tumor development. PMID: 18806743
16. Murine beta-defensin (mBD)2, but not mBD1, is required for host resistance against Pseudomonas aeruginosa-induced corneal infection. PMID: 19155510
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亞細胞定位：

Secreted.
蛋白家族：

Beta-defensin family
組織特異性：

Kidney, uterus and to a lesser extent in heart.
數據庫鏈接：

KEGG: mmu:13215

STRING: 10090.ENSMUSP00000006745

UniGene: Mm.41981