Recombinant Human Glutamate receptor, ionotropic kainate 4 (GRIK4), partial

中文名稱：

人GRIK4重組蛋白
貨號：

CSB-YP619054HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人GRIK4重組蛋白
貨號：

CSB-EP619054HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人GRIK4重組蛋白
貨號：

CSB-EP619054HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GRIK4重組蛋白
貨號：

CSB-BP619054HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人GRIK4重組蛋白
貨號：

CSB-MP619054HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GRIK4
Uniprot No.：

Q16099
別名：

EAA 1; EAA1; Excitatory amino acid receptor 1; GluK4; Glutamate receptor; Glutamate receptor ionotropic kainate 4; Glutamate receptor ionotropic kainate 4 precursor; Glutamate receptor KA 1; Glutamate receptor KA 1precursor; Glutamate receptor KA-1; Glutamate receptor KA1; Glutamate receptor; ionotropic kainate 4; GRIK 4; GRIK; Grik4; GRIK4_HUMAN; ionotropic kainate 4; KA 1; KA1; OTTHUMP00000045951; OTTHUMP00000231881
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
基因功能參考文獻：
1. the GRIK4 polymorphisms genotypes were distributed as follows: rs79526501: CC696: 16, CG302: 274, GG31: 35; rs11218016: CC455: 483, CT473: 436, TT101: 108; and rs6589847: AA32: 29, AG307: 314, GG690: 686. However, there was no significant difference in allelic or genotypic frequency distributions between patients and controls. We did not find any significant association between GRIK4 polymorphisms and schizophrenia. PMID: 28658089
2. Results firstly indicated that rs56275759 of GRIK4 gene might be associated with major depressive disorder in Chinese Han population. PMID: 28583584
3. This study showed the lower GluK4 mRNA levels in pregnant women. PMID: 28284346
4. Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes. PMID: 26139080
5. Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment. PMID: 25303296
6. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. PMID: 22052594
7. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production. PMID: 21215464
8. The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment. PMID: 19924111
9. Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate hypothesis' of psychotic illness. PMID: 16819533
10. An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found. PMID: 18824690
11. This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function. PMID: 19384319
顯示更多

收起更多
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK4 subfamily
數據庫鏈接：

HGNC: 4582

OMIM: 600282

KEGG: hsa:2900

STRING: 9606.ENSP00000404063

UniGene: Hs.538738