GRIK4 Antibody, Biotin conjugated

說明書

中文名稱：

GRIK4兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA619054LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GRIK4 Polyclonal antibody
Uniprot No.：

Q16099
基因名：

GRIK4
別名：

EAA 1 antibody; EAA1 antibody; Excitatory amino acid receptor 1 antibody; GluK4 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 4 antibody; Glutamate receptor ionotropic kainate 4 precursor antibody; Glutamate receptor KA 1 antibody; Glutamate receptor KA 1precursor antibody; Glutamate receptor KA-1 antibody; Glutamate receptor KA1 antibody; Glutamate receptor; ionotropic kainate 4 antibody; GRIK 4 antibody; GRIK antibody; Grik4 antibody; GRIK4_HUMAN antibody; ionotropic kainate 4 antibody; KA 1 antibody; KA1 antibody; OTTHUMP00000045951 antibody; OTTHUMP00000231881 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Glutamate receptor ionotropic, kainate 4 protein (826-956AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
基因功能參考文獻：
1. the GRIK4 polymorphisms genotypes were distributed as follows: rs79526501: CC696: 16, CG302: 274, GG31: 35; rs11218016: CC455: 483, CT473: 436, TT101: 108; and rs6589847: AA32: 29, AG307: 314, GG690: 686. However, there was no significant difference in allelic or genotypic frequency distributions between patients and controls. We did not find any significant association between GRIK4 polymorphisms and schizophrenia. PMID: 28658089
2. Results firstly indicated that rs56275759 of GRIK4 gene might be associated with major depressive disorder in Chinese Han population. PMID: 28583584
3. This study showed the lower GluK4 mRNA levels in pregnant women. PMID: 28284346
4. Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes. PMID: 26139080
5. Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment. PMID: 25303296
6. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. PMID: 22052594
7. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production. PMID: 21215464
8. The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment. PMID: 19924111
9. Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate hypothesis' of psychotic illness. PMID: 16819533
10. An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found. PMID: 18824690
11. This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function. PMID: 19384319
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
蛋白家族：

Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK4 subfamily
數據庫鏈接：

HGNC: 4582

OMIM: 600282

KEGG: hsa:2900

STRING: 9606.ENSP00000404063

UniGene: Hs.538738

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