Recombinant Human Enoyl-CoA delta isomerase 2, mitochondrial (ECI2)

中文名稱：

人ECI2重組蛋白
貨號：

CSB-YP527983HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人ECI2重組蛋白
貨號：

CSB-EP527983HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人ECI2重組蛋白
貨號：

CSB-EP527983HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ECI2重組蛋白
貨號：

CSB-BP527983HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人ECI2重組蛋白
貨號：

CSB-MP527983HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ECI2
Uniprot No.：

O75521
別名：

2-trans-enoyl-CoA isomerase; ACBD2 ; acyl Coenzyme A binding domain containing 2 ; D2-enoyl-CoA isomerase; D3; D3 D2 enoyl CoA isomerase; DBI related protein 1 ; DBI-related protein 1; delta(2)-enoyl-CoA isomerase; Delta(3); Delta(3) delta(2) enoyl CoA isomerase; Diazepam-binding inhibitor-related protein 1; Dodecenoyl CoA isomerase; Dodecenoyl-CoA isomerase; DRS 1 ; DRS-1; DRS1 ; Eci2; ECI2_HUMAN; Enoyl-CoA delta isomerase 2; HCA88 ; Hepatocellular carcinoma associated antigen 88; Hepatocellular carcinoma-associated antigen 88; mitochondrial; pECI; Peroxisomal 3; Peroxisomal 3,2-trans-enoyl-CoA isomerase; Peroxisomal D3 D2 enoyl CoA isomerase; Renal carcinoma antigen NY REN 1 ; Renal carcinoma antigen NY-REN-1
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

39-394
氨基酸序列

SQ KDFENSMNQV KLLKKDPGNE VKLKLYALYK QATEGPCNMP KPGVFDLINK AKWDAWNALG SLPKEAARQN YVDLVSSLSP SLESSSQVEP GTDRKSTGFE TLVVTSEDGI TKIMFNRPKK KNAINTEMYH EIMRALKAAS KDDSIITVLT GNGDYYSSGN DLTNFTDIPP GGVEEKAKNN AVLLREFVGC FIDFPKPLIA VVNGPAVGIS VTLLGLFDAV YASDRATFHT PFSHLGQSPE GCSSYTFPKI MSPAKATEML IFGKKLTAGE ACAQGLVTEV FPDSTFQKEV WTRLKAFAKL PPNALRISKE VIRKREREKL HAVNAEECNV LQGRWLSDEC TNAVVNFLSR KSKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.
基因功能參考文獻：
1. Enoyl-CoA delta isomerase 2 (ECI2) is a novel AR-target that promotes prostate cancer cell survival PMID: 28415728
2. Ectopic expression of the ACBD2/ECI2 isoform A in MA-10 cells led to increased basal and hormone-stimulated steroid formation, indicating that ACBD2/ECI2-mediated peroxisomes-mitochondria interactions favor in the exchange of metabolites and/or macromolecules between these 2 organelles in support of steroid biosynthesis. Considering the widespread occurrence of the ACBD2/ECI2 protein, we propose that this protein might se PMID: 27167610
3. Disruption of mitochondrial beta -oxidation of unsaturated fatty acids in the 3,2-trans-enoyl-CoA isomerase-deficient mouse PMID: 11916962
4. DRS-1 may serve as an autoantigen eliciting immune attack against hematopoietic stem cells in a subset of acquired aplastic anemia patients characterized by increased paroxysmal nocturnal hemoglobinuria-type cells PMID: 15217832
亞細胞定位：

[Isoform 1]: Mitochondrion.; [Isoform 2]: Peroxisome matrix.
蛋白家族：

Enoyl-CoA hydratase/isomerase family
組織特異性：

Abundant in heart, skeletal muscle and liver. Expressed in CD34(+) T-cells and CD34(+) bone marrow cells.
數據庫鏈接：

HGNC: 14601

OMIM: 608024

KEGG: hsa:10455

STRING: 9606.ENSP00000369461

UniGene: Hs.15250