Recombinant Human Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)

中文名稱：
貨號：

CSB-YP2273HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP2273HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP2273HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP2273HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP2273HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PDE1A
Uniprot No.：

P54750
別名：

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; EC 3.1.4.17; 61 kDa Cam-PDE; hCam-1; PDE1A
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
基因功能參考文獻：
1. evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts. PMID: 29262781
2. Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness. PMID: 26464516
3. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis PMID: 22012077
4. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1. PMID: 20807569
5. PDE1A is permanently activated in human spermatozoa PMID: 12135876
6. Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+ PMID: 15272012
7. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis. PMID: 16514069
8. Variants in PDE1A are not associated with citalopram response in patient with depression. PMID: 18043711
9. PDE1A is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142
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蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
組織特異性：

Several tissues, including brain, kidney, testes and heart.
數據庫鏈接：

HGNC: 8774

OMIM: 171890

KEGG: hsa:5136

STRING: 9606.ENSP00000331574

UniGene: Hs.191046