PDE1A Antibody

中文名稱：

PDE1A兔多克隆抗體
貨號：

CSB-PA22739A0Rb
規(guī)格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA22739A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PDE1A Polyclonal antibody
Uniprot No.：

P54750
基因名：

PDE1A
別名：

3' 5' cyclic nucleotide phosphodiesterase antibody; 5''-cyclic nucleotide phosphodiesterase 1A antibody; 61 kDa Cam PDE antibody; 61 kDa Cam-PDE antibody; Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A antibody; Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase antibody; Calcium/calmodulin-dependent 3'' antibody; Calmodulin-dependent Phosphodiesterase antibody; Cam PDE 1A antibody; Cam-PDE 1A antibody; CAM-PDE-1A antibody; HCAM 1 antibody; hCam-1 antibody; HCAM1 antibody; HSPDE1A antibody; MGC26303 antibody; PDE 1A antibody; PDE1A antibody; PDE1A_HUMAN antibody; Phosphodiesterase 1A antibody; Phosphodiesterase 1A calmodulin dependent antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A protein (1-219AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PDE1A Antibody (CSB-PA22739A0Rb)，的標記方式是Non-conjugated。對于PDE1A Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA22739B0Rb	PDE1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA22739C0Rb	PDE1A Antibody, FITC conjugated
Biotin	CSB-PA22739D0Rb	PDE1A Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
基因功能參考文獻：
1. evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts. PMID: 29262781
2. Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness. PMID: 26464516
3. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis PMID: 22012077
4. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1. PMID: 20807569
5. PDE1A is permanently activated in human spermatozoa PMID: 12135876
6. Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+ PMID: 15272012
7. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis. PMID: 16514069
8. Variants in PDE1A are not associated with citalopram response in patient with depression. PMID: 18043711
9. PDE1A is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142
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蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE1 subfamily
組織特異性：

Several tissues, including brain, kidney, testes and heart.
數(shù)據(jù)庫鏈接：

HGNC: 8774

OMIM: 171890

KEGG: hsa:5136

STRING: 9606.ENSP00000331574

UniGene: Hs.191046

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