Recombinant Human AMP deaminase 2 (AMPD2), partial

中文名稱：

Recombinant Human AMP deaminase 2(AMPD2) ,partial
貨號：

CSB-YP001681HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human AMP deaminase 2(AMPD2) ,partial
貨號：

CSB-EP001681HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human AMP deaminase 2(AMPD2) ,partial
貨號：

CSB-EP001681HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human AMP deaminase 2(AMPD2) ,partial
貨號：

CSB-BP001681HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human AMP deaminase 2(AMPD2) ,partial
貨號：

CSB-MP001681HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

AMPD2
Uniprot No.：

Q01433
別名：

Adenosine monophosphate deaminase 2 (isoform L); Adenosine monophosphate deaminase 2; adenosine monophosphate deaminase 2 isoform L; AMP deaminase 2; AMP deaminase isoform L; AMPD 2; AMPD; AMPD2; AMPD2_HUMAN; RP5-1160K1.5; SPG63
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
基因功能參考文獻：
1. Here we report the clinical and genetic analysis of an individual with PCH9 secondary to a novel missense variant with strong evidence of pathogenicity, located outside the catalytic domain of AMPD2 PMID: 28168832
2. tofacitinib increases the cellular levels of adenosine, which is known to have anti-inflammatory activity, through the downregulation of AMPD2. This would be a novel functional aspect of tofacitinib. PMID: 25496463
3. In human HepG2 cells, AMPD2 activation counterregulates AMPK and increases intracellular glucose production, in association with up-regulation of PEPCK and G6Pc. PMID: 24755741
4. Study concluded that AMPD2 as necessary for guanine nucleotide biosynthesis and protein translation and provide evidence that AMP deaminase activity is critical during neurogenesis. Patients with mutations in AMPD2 have characteristic brain imaging features of pontocerebellar hypoplasia due to loss of brainstem and cerebellar parenchyma. PMID: 23911318
5. N-terminal extensions of the AMPD2 polypeptide influence ATP regulation of isoform L. PMID: 12745092
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相關疾病：

Pontocerebellar hypoplasia 9 (PCH9); Spastic paraplegia 63, autosomal recessive (SPG63)
蛋白家族：

Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family
組織特異性：

Highly expressed in cerebellum.
數據庫鏈接：

HGNC: 469

OMIM: 102771

KEGG: hsa:271

STRING: 9606.ENSP00000256578

UniGene: Hs.82927