Recombinant Chicken Protection of telomeres protein 1 (POT1), partial

中文名稱：

雞POT1重組蛋白
貨號：

CSB-YP018382CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

雞POT1重組蛋白
貨號：

CSB-EP018382CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

雞POT1重組蛋白
貨號：

CSB-EP018382CH-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞POT1重組蛋白
貨號：

CSB-BP018382CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

雞POT1重組蛋白
貨號：

CSB-MP018382CH
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

POT1
Uniprot No.：

P62597
別名：

POT1; Protection of telomeres protein 1; cPot1; POT1-like telomere end-binding protein
種屬：

Gallus gallus (Chicken)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex that is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Binds to at least two telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand). Its activity is TERT dependent but it does not increase TERT activity.
基因功能參考文獻(xiàn)：
1. Endogenous chicken Pot1 is present at telomeres during periods of the cell cycle when t loops are thought to be present in DNA. PMID: 14966288
2. These data indicate that vertebrate POT1 is required for telomere capping but that it functions quite differently from TRF2. PMID: 16943437
3. an electrophoretic mobility shift assay and isothermal titration calorimetry analyses of the binding ability of the site-directed mutants indicated that only five amino acids significantly contributed to telomeric DNA recognition of Pot1 PMID: 17284852
亞細(xì)胞定位：

Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA.
蛋白家族：

Telombin family
數(shù)據(jù)庫鏈接：

KEGG: gga:404538

STRING: 9031.ENSGALP00000014206

UniGene: Gga.11620