UQCRC2 Recombinant Monoclonal Antibody
-
中文名稱：UQCRC2 Recombinant Monoclonal Antibody
-
貨號：CSB-RA827808A0HU
-
規格：￥1320
-
圖片：
-
Flow cytometric analysis of UQCRC2 expression in HepG2 cells using UQCRC2 antibody. Green, isotype control; red, UQCRC2. -
Immunocytochemical staining of HepG2 cells with UQCRC2 antibody. Nuclei were stained blue with DAPI; UQCRC2 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm. -
Western blotting analysis using UQCRC2 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with UQCRC2 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
-
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：
-
別名：UQCRC2; Ubiquinol-Cytochrome C Reductase Core Protein 2; UQCR2; QCR2; Ubiquinol-Cytochrome-C Reductase Complex Core Protein 2; Ubiquinol-Cytochrome C Reductase Core Protein II; Cytochrome B-C1 Complex Subunit 2, Mitochondrial; Complex III Subunit; Cytochrome Bc-1 Complex Core Protein II; Core Protein II; MC3DN5
-
反應種屬：Human, Rat
-
免疫原：Recombinant Human UQCRC2 protein
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
克隆類型：Monoclonal
-
抗體亞型：Rabbit IgG
-
純化方式：Affinity-chromatography
-
克隆號：24A12
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
-
產品提供形式：Liquid
-
應用范圍：ELISA, WB, FC, ICC
-
推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 FC 1:200-1:2000 ICC 1:100-1:1000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).
-
基因功能參考文獻：
- These results provided novel insights into the potential role of UQCRC2 in the tumorigenesis and progression of colorectal cancer PMID: 30115536
- Down-regulation of UQCRC2 partly reversed the inhibition of invasion/migration ability and chemoresistance in CDH18 overexpressed glioma cell lines. PMID: 30078018
- These data indicate that a homozygous missense mutation in UQCRC2 causes moderately impaired CIII function and severely decreased amounts of CIII and supercomplex, which would be the primary molecular pathogenesis in the patients. PMID: 23281071
-
相關疾病：Mitochondrial complex III deficiency, nuclear 5 (MC3DN5)
-
亞細胞定位：Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
-
蛋白家族：Peptidase M16 family, UQCRC2/QCR2 subfamily
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
