TYMS Recombinant Monoclonal Antibody
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中文名稱：TYMS Recombinant Monoclonal Antibody
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貨號：CSB-RA279848A0HU
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規格：￥1320
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圖片：
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Flow cytometric analysis of thymidylate synthetase expression in HepG2 cells using thymidylate synthetase antibody. Green, isotype control; red, thymidylate synthetase. -
Immunocytochemical staining of HepG2 cells with Thymidylate synthetase antibody. Nuclei were stained blue with DAPI; Thymidylate synthetase was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Meduim. Scale bar: 20 μm. -
Western blotting analysis using thymidylate synthetase antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with thymidylate synthetase antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：TYMS; Thymidylate Synthetase; HsT422; Tsase; TMS; TS; Thymidylate Synthase; EC 2.1.1.45; TSase; DKCD
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反應種屬：Human, Mouse
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免疫原：Recombinant Human TYMS protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：21B6
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, FC, ICC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 FC 1:200-1:2000 ICC 1:100-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
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基因功能參考文獻：
- The nasopharyngeal carcinoma patients with positive LRP and TS expression may be less sensitive to chemotherapy with DDP + 5-FU. PMID: 15952572
- high level of expression associated with poor prognosis in p-stage I adenocarcinoma of the lung PMID: 11804689
- Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles PMID: 11989786
- Mutants of TS that confer resistance to MTX as well as 5-FU by random as well as site-directed mutagenesis. Review. PMID: 12084458
- Thymidylate synthase as a translational regulator of cellular gene expression. Review. PMID: 12084459
- rTS gene expression likely plays a role in down-regulating TS through a natural RNA-based antisense mechanism. Review. PMID: 12084460
- Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. Review. PMID: 12084461
- Structure-based studies on species-specific inhibition of thymidylate synthase. Review. PMID: 12084462
- mutations in TS result in conformational changes that confer 5-fluordeoxyuridine resistance PMID: 12147691
- TYMS and MTHFR compete for limiting supplies of folate required for the remethylation of homocysteine. PMID: 12215845
- the identified highly conserved protein domains, which occur at the homodimeric interface of thymidylate synthase(TS), represent potential participating sites for binding of TS protein to its mRNA. PMID: 12220503
- Enhanced expression mediates resistance of uterine cervical cancer cells to radiation PMID: 12239455
- cytomegalovirus infection induces cellular thymidylate synthase gene expression in quiescent human embryonic lung fibroblasts PMID: 12466474
- Gene expression is a predictor for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. PMID: 12576451
- Expression predicts the reponse of metastatic colorectal cancer to raltitrexel. PMID: 12576452
- Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. PMID: 12604405
- polymorphism and overexpression of Thymidylate synthase mrna is associated with non-small-cell lung cancer PMID: 12640689
- Results suggest that the genotyping for thymidylate synthase and methylenetetrahydrofolate reductase polymorphisms may be a useful indicator in determining the appropriate dose of methotrexate in patients with rheumatoid arthritis. PMID: 12684695
- Overexpression of thymidylate synthase mediates desensitization for 5-fluorouracil of cervical cancer cells PMID: 12845668
- Results describe the kinetic parameters of human recombinant thymidylate synthase (hrTS) with its natural substrate, dUMP, and E-5-(2-bromovinyl)-2(')-deoxyuridine monophosphate (BVdUMP). PMID: 12859954
- Findings identify Cys-180 as a critical residue for the in vitro and in vivo translational regulatory effects of human thymidylate synthase. PMID: 12907731
- TS and DPD quantitation may be helpful to evaluate prognosis of patients receiving adjuvant 5-FU and that patients with high TS and low DPD may benefit from adjuvant 5-FU chemotherapy in colorectal cancer. PMID: 14519634
- High TS expression is a marker of poor prognosis in resected pancreatic cancer. Patients with high intratumoral TS expression benefit from adjuvant therapy. PMID: 14519641
- These results indicate that postoperative chemotherapy with 5-FU could be effective for patients with the G-phenotype tumor, since the incidence of intratumoral expression of TS, the target enzyme of 5-FU, is significantly low in G-phenotype tumors PMID: 14576935
- There is prognostic significance to TS mRNA expression in breast neoplasms. PMID: 14702180
- thymidylate synthase loss of heterozygosity has a role in progression of colorectal cancer PMID: 14760062
- Molecular features of thymidylate synthase that control its degradation are examined; the carboxyl-terminal conformational shift is not required for ligand-mediated stabilization; the amino-terminus governs TS stability and its response to ligands. PMID: 14967037
- TYMS gene amplification in 23% of 31 5-FU-treated cancers, whereas no amplification was observed in metastases of patients that had not been treated with 5-FU. PMID: 14970324
- Over expression of Thymidylate synthase exhibits oncogene-like activity and suggest a link between DNA synthesis and the induction of a neoplastic phenotype PMID: 15093541
- 6 bp/1494 polymorphism varies greatly within different ethnic populations and is in linkage disequilibrium with the thymidylate synthase 5' tandem repeat enhancer polymorphism PMID: 15115918
- Polymorphism of TYMS partially modifies the risk of esophageal and stomach cancer in patients with smoking habit. PMID: 15244514
- Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells PMID: 15251465
- The combination of low expression of TS and induction of p16(INK4a) after chemotherapy can be important indicators of the sensitivity to 5-FU-based chemotherapy in colorectal cancers. PMID: 15260847
- Thymidylate synthase polymorphisms are associated with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma PMID: 15284183
- TS in malignant tissue was statistically higher than in normal stromal tissue in both differentiated and undifferentiated types (p < 0.0001). PMID: 15316940
- Polymorphisms in the TS gene may contribute to gastric cancer susceptibility. PMID: 15386366
- Polymorphisms of reduced folate carrier,aminoimidazole carboxamide ribonucleotide transformylase,and thymidylate synthase genes contribute to the therapeutic response in rheumatoid arthritis patients to methotrexate. PMID: 15457444
- The common MTHFR C677T and TS enhancer region polymorphisms were not risk factors for breast cancer in this patient cohort nor were they associated with phenotypic features or with prognosis. PMID: 15510613
- Thymidylate synthase polymorphism may have a role in colorectal cancer PMID: 15571262
- there is a high level of homology in polymorphic status of thymidylate synthase between normal and malignant colonic tissues PMID: 15571263
- thymidylate synthase is inhibited by trifluorothymidine in human tumor cells PMID: 15571283
- Thymidylate synthase 5'- and 3'-untranslated region polymorphisms are associated with risk and progression of squamous cell carcinoma of the head and neck PMID: 15585623
- Our findings suggest that the TYMS 3'UTR del/del genotype is a significant determinant of elevated RBC folate concentration in a non-smoking population PMID: 15682292
- Investigators found a relationship between the TSmRNA expression, evaluated by real-time PCR, and with the TS level determined by immunohistochemical assay in colorectal cancer. PMID: 15736425
- High TS1 gene expression is associated with chemotherapy resistance in esophageal cancer PMID: 15788669
- Important role for folate deficiency and impaired TS activity in the etiology of esophagel and gastric cancer. PMID: 15817609
- Polymorphisms in the 5'- and 3'-untranslated regions are a risk factor for gastric cancer in China. PMID: 15930032
- TS polymorphism may be a genetic determinant of plasma homocysteine level in Korean patients with recurrent spontaneous abortion. PMID: 15985285
- thymidylate synthase and dihydropyrimidine dehydrogenase are involved in resistance to 5-fluorouracil in human lung cancer cells PMID: 15993511
- thymidylate synthase and orotate phosphoribosyl transferase, but not dihydropyrimidine dehydrogenase, are more highly expressed in prostate cancer than in benign prostatic hyperplasia PMID: 15999119
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亞細胞定位：Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.
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蛋白家族：Thymidylate synthase family
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