PSME1 Recombinant Monoclonal Antibody

說明書

中文名稱：

PSME1 Recombinant Monoclonal Antibody
貨號：

CSB-RA960183A0HU
規格：

￥1320
圖片：
Flow cytometric analysis of proteasome activator subunit 1 expression in HT-1080 cells using proteasome activator subunit 1 antibody. Green, isotype control; red, proteasome activator subunit 1.

Immunocytochemical staining of HT-1080 cells with proteasome activator subunit 1 antibody. Nuclei were stained blue with DAPI; Proteasome activator subunit 1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.

Western blotting analysis using proteasome activator subunit 1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with proteasome activator subunit 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q06323
基因名：

PSME1
別名：

Proteasome Activator Subunit 1; PA28alpha; IFI5111; Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha); Activator Of Multicatalytic Protease Subunit 1; Interferon Gamma Up-Regulated I-5111 Protein; Proteasome Activator Complex Subunit 1; 11S Regulator Complex Subunit Alpha; IGUP I-5111; Epididymis Secretory Sperm Binding Protein Li 129m; Interferon-Gamma-Inducible Protein 5111; Proteasome Activator 28 Subunit Alpha; Interferon-Gamma IEF SSP 5111; 29-KD MCP Activator Subunit; HEL-S-129m; REG-Alpha; REGalpha; PA28A; PA28a
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human PSME1 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

2F5
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, FC, ICC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
FC	1:200-1:2000
ICC	1:100-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Flow cytometry (FC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
基因功能參考文獻：
1. Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the proteasome activator PA28ab PMID: 26944190
2. Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival. PMID: 26892607
3. Constitutive expression of PA28 and ERAP1 in melanoma cells indicate that both interfere with MART-1(26-35) epitope generation even in the absence of IFN-gamma PMID: 26399368
4. PA28 is a tumor marker and a potential target for therapeutic intervention in prostate cancer. PMID: 23918357
5. Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNbeta in mouse pancreatic beta-cells. PMID: 23383295
6. the first evidence of a novel ovarian cancer-specific marker PMID: 22532226
7. PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen. PMID: 12200048
8. The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex. PMID: 14760793
9. DJ-1 and PA28alpha may have roles in the onset of hepatocarcinogenesis PMID: 17671684
10. the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer PMID: 17939699
11. bortezomib-adapted HL-60 cells showed increased expression and proteasome association of the 11S proteasome activator PMID: 19225532
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蛋白家族：

PA28 family
數據庫鏈接：

HGNC: 9568

OMIM: 600654

KEGG: hsa:5720

STRING: 9606.ENSP00000372155

UniGene: Hs.75348

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