LSP1 Recombinant Monoclonal Antibody
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中文名稱：LSP1 Recombinant Monoclonal Antibody
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貨號：CSB-RA955655A0HU
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規(guī)格：￥1320
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圖片：
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Western Blot
, Positive WB detected in:Jurkat whole cell lysate(30μg), HL-60 whole cell lysate(30μg), U937 whole cell lysate(30μg)
All lanes: LSP1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 37 kDa
Observed band size:52 kDa
Exposure time：180s -
IHC image of CSB-RA955655A0HU diluted at 1:100 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：LSP1
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別名：47 kDa actin binding protein antibody; 47 kDa actin-binding protein antibody; 52 kDa phosphoprotein antibody; F actin binding and cytoskeleton associated protein antibody; Leufactin (leukocyte F-actin binding protein) antibody; Leufactin antibody; Leukocyte F actin binding protein antibody; Leukocyte specific protein 1 antibody; LSP 1 antibody; Lsp1 antibody; LSP1_HUMAN antibody; Lymphocyte specific antigen WP34 antibody; Lymphocyte specific protein 1 antibody; Lymphocyte specific protein pp52 antibody; Lymphocyte-specific antigen WP34 antibody; Lymphocyte-specific protein 1 antibody; OTTHUMP00000014138 antibody; OTTHUMP00000014139 antibody; OTTHUMP00000014140 antibody; OTTHUMP00000069612 antibody; OTTHUMP00000069614 antibody; OTTHUMP00000069615 antibody; OTTHUMP00000069616 antibody; pp52 antibody; Protein pp52 antibody; S37 protein antibody; WP 34 antibody; WP34 antibody
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反應(yīng)種屬：Human
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免疫原：A synthesized peptide from human LSP1 protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：24F9
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May play a role in mediating neutrophil activation and chemotaxis.
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基因功能參考文獻(xiàn)：
- LSP1 rs3817198 T > C polymorphism is associated with increased risk of breast cancer, especially in Caucasian and Asian populations [meta-analysis] PMID: 27590509
- These results show that LSP1 is critical regulator of actomyosin contractility in primary macrophages. PMID: 29410425
- Underexpression of LSP1 is associated with Breast Cancer Recurrence. PMID: 27165221
- LSP1 rs569550 and rs592373 polymorphisms are both risk factors for breast cancer. PMID: 26191300
- the importance of LSP1 Copy number variations and LSP1 insufficiency in the pathogenesis of rheumatoid arthritis, is reported. PMID: 26554018
- The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio: 1.10) This association was strongest for women with adenocarcinoma (P = 1.2x10(-4)). PMID: 24681604
- Data indicate that slit2N alters the localization and binding of Robo1 to WASp and LSP1 in HIV-1-gp120-treated immature dendritic cells (iDCs). PMID: 23119100
- Single nucleotide polymorphism in LSP1 is associated with breast cancer. PMID: 22454379
- The LSP1 rs3817198T>C polymorphism is a low-penetrant risk factor for developing breast cancer but may not be in Africans. PMID: 21127985
- Low-risk variants of LSP1 is associated with familial breast cancer. PMID: 19856316
- The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. PMID: 19656774
- LSP1 interacts with F-actin and the cytoskeleton through residues downstream of amino acid residue 230. The cytoskeleton binding site of mouse LSP1 maps to the 300-330 interval. PMID: 12972289
- Leukocyte-specific protein 1 is a cytoskeletal targeting protein for the ERK/MAP kinase pathway PMID: 15090600
- LSP1 protein facilitates virus transport into the proteasome after its interaction with DC-SIGN through its interaction with cytoskeletal proteins. PMID: 17296787
- MK2-regulated LSP1 phosphorylation is involved in stabilization of F-actin polarization during neutrophil chemotaxis. PMID: 17481585
- DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1 PMID: 19718030
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亞細(xì)胞定位：Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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組織特異性：Activated T-lymphocytes.
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