GDF3 Recombinant Monoclonal Antibody

說明書

中文名稱：

GDF3 Recombinant Monoclonal Antibody
貨號：

CSB-RA147504A0HU
規格：

￥1320
圖片：
Western blotting analysis using Growth differentiation factor 3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Growth differentiation factor 3 antibody and HRP-conjugated goat rabbit secondary antibody respectively.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NR23
基因名：

GDF3
別名：

GDF3; Growth Differentiation Factor 3; Growth/Differentiation Factor 3; MCOPCB6; MCOP7; GDF-3; KFS3
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human GDF3 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

13A10
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto. Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto.
基因功能參考文獻：
1. the 4 of the 5 variants in [i]GDF3[/i] gene contribute different pathogenicity in congenital scoliosis, which may provide molecular evidence for clinical genetic testing. PMID: 29735971
2. OCT4 plays a role as a transcriptional activator for GDF3 transcription in pluripotent human embryonic carcinoma NCCIT cells and contributes to the understanding of the molecular networks of stem cell regulators in germ cell-derived pluripotency and tumorigenesis. PMID: 27803451
3. The results expand the spectrum of mutations associated with CHDs and first suggest the potentially disease-related GDF3 gene variant in the pathogenesis of CHDs. PMID: 25372014
4. first evidence that NANOG is a transcriptional activator of the expression of the oncogenic growth factor GDF3 in embryonic carcinoma cells PMID: 22963770
5. GDF3 expression level was significantly down-regulated in breast cancer tissues compared to the surrounding nontumorous tissues. PMID: 22488170
6. the conditioned medium from CHO-GDF3 could reduce PC12 cell growth and induce cell differentiation PMID: 21805089
7. Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells. PMID: 22305102
8. Mutation of GDF3 causes ocular and skeletal anomalies. PMID: 19864492
9. Present data suggested that GDF3 might play important roles in the central nervous system (CNS), especially in cerebral cortex, hippocampus and cerebellum, and it shed new light on further research of GDF3 in the central nervous system. PMID: 16126341
10. GDF3 regulates both of the two major characteristics of embryonic stem cells: the ability to maintain the undifferentiated state and the ability to differentiate into the full spectrum of cell types. PMID: 16339188
11. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID: 18480259
12. GDF3 is either a bi-functional TGF-beta ligand, or, more likely, that it is a BMP inhibitor that can artificially activate Nodal signaling under non-physiological conditions. PMID: 18823971
13. GDF3 positivity is helpful in the diagnosis of yolk sac tumor PMID: 19396148
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相關疾病：

Klippel-Feil syndrome 3, autosomal dominant (KFS3); Microphthalmia, isolated, with coloboma, 6 (MCOPCB6); Microphthalmia, isolated, 7 (MCOP7)
亞細胞定位：

Secreted. Cytoplasm.
蛋白家族：

TGF-beta family
數據庫鏈接：

HGNC: 4218

OMIM: 606522

KEGG: hsa:9573

STRING: 9606.ENSP00000331745

UniGene: Hs.86232

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