FCGR2A (muIV.3) Recombinant Monoclonal Antibody
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中文名稱：FCGR2A (muIV.3) Recombinant Monoclonal Antibody
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貨號(hào)：CSB-RA008540MA1HU
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規(guī)格：￥1320
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圖片：
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The Binding Activity of Human FCGR2A with Anti-FCGR2A Recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human FCGR2A (CSB-MP008540HU1) at 2 μg/mL can bind Anti-FCGR2A recombinant antibody. The EC50 is 24.44-32.57 ng/mL.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：CD32 antibody; CD32 antigen antibody; CDw32 antibody; Fc fragment of IgG; low affinity IIa; receptor (CD32) antibody; Fc fragment of IgG; low affinity IIa; receptor for (CD32) antibody; Fc gamma RII a antibody; Fc gamma RIIa antibody; Fc-gamma RII-a antibody; Fc-gamma-RIIa antibody; FCG2 antibody; FCG2A_HUMAN antibody; FcGR antibody; FCGR2 antibody; FCGR2A antibody; FCGR2A1 antibody; FcRII a antibody; FcRII-a antibody; IGFR2 antibody; IgG Fc receptor II a antibody; IgG Fc receptor II-a antibody; Immunoglobulin G Fc receptor II antibody; low affinity immunoglobulin gamma Fc region receptor II a antibody; Low affinity immunoglobulin gamma Fc region receptor II-a antibody
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反應(yīng)種屬：Human
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免疫原：Recombinant Human FCGR2A protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號(hào)：5H2
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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推薦稀釋比：
Application Recommended Dilution ELISA 1:5000-1:50000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
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基因功能參考文獻(xiàn)：
- The results demonstrate that CD32 expression is a marker of CD4+ T cell activation in HIV+ individuals. PMID: 30013105
- this study shows that genetic variation of human neutrophil Fcgamma receptors and SIRPalpha in antibody-dependent cellular cytotoxicity towards cancer cells PMID: 28952147
- this study shows that FCGR genetic polymorphism affects antibody responses to GARP in patients with breast cancer PMID: 29879453
- Data indicate that the Fc gamma receptor FCgammaRIIA polymorphisms did not significantly influence response to rituximab in immune thrombocytopenic purpura (ITP). PMID: 28856973
- Results showed significantly higher frequency of FC gamma receptor FCGR3A-158V allele in patients with immune thrombocytopenia (ITP) compared with control subjects, but not significant differences in the genotype distribution or allele frequencies for FC gamma receptor FCGR2A-131H/R between patients and controls. PMID: 28942727
- Differently oxidized isolated subspecies can lead both to stronger as well as weaker binding and activation of the histidine variant of Fc fragment of IgG receptor IIa (FcgammaRIIa). PMID: 28988621
- CRP bound to surface CD32 (also known as FcgammaRII) on myeloma cells, which activated a pathway mediated by the kinase p38 MAPK and the transcription factor Twist that enhanced the cells' secretion of osteolytic cytokines. PMID: 29233917
- FCGR2A single nucleotide polymorphism confers susceptibility to idiopathic nephrotic syndrome PMID: 29155175
- alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia. PMID: 28815933
- The expression levels of human FcgammaRIIB but not FcgammaRIIA were negatively correlated with serum levels of IgE in human asthma patients. PMID: 29597194
- When higher-affinity genotypes for FCGR2A, FCGR3A, and FCGR2C were considered together, they were associated with significantly increased tumor shrinkage and prolonged survival in response to HD-IL2... this is the first study to show associations of FCGR genotypes with outcome following HD-IL2 treatment PMID: 27742794
- FcgammaRIIA and FcgammaRIIB both demonstrated increased methylation levels in Kawasaki disease (KD) patients that underwent IVIG treatment. FcgammaRIIA expression influenced the IVIG treatment response of KD patients. The FcgammaRIIA/IIB mRNA expression ratio was greater in KD patients with coronary artery lesion formation. PMID: 27893416
- FCGR2A rs1801274 G-allele confers susceptibility to Kawasaki disease and Ulcerative colitis PMID: 27270653
- farletuzumab has enhanced binding to FCGR3A-158V high-affinity receptor and has an enhanced clinical outcome in ovarian cancer patients with low baseline CA125 levels and at least 1 high-affinity allele of FCGR2A or FCGR3A PMID: 29041009
- inhibition of Abl/Src with bosutinib reduced FcgammaRIIA-mediated glomerular neutrophil accumulation and renal injury in experimental, crescentic anti-GBM nephritis. PMID: 28891817
- The present study demonstrates that p.His167Arg, a KD-associated FCGR2A variant, acts as a susceptibility gene in males only. Overall, the gender differences associated with FCGR2A in KD provide a new insight into KD susceptibility. PMID: 28886140
- Data indicate a mechanism in which Toll-like receptors TLR7/8 signaling, through shedding of FcgRIIA, shifts neutrophil function from phagocytosis to a programmed necrosis pathway, neutrophil extracellular trap formation (NETosis). PMID: 28606989
- Gene copy number variation (CNV) of the PKLR, FCGR2A, FCGR2C, and FCGR3 genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria. PMID: 28605553
- This study demonstrated that no association between FCGR2A polymorphisms in Guillain-Barre Syndrome in a Brazilian population. PMID: 27609290
- FCGR3A V and FCGR2A R allele carriers show better responsiveness to anti-TNF-alpha therapy--{REVIEW} PMID: 27490376
- Association between Fc gamma receptor IIA genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya. PMID: 28427365
- identification of a subpopulation of 0.012% of CD4 T cells that express CD32a and host up to three copies of HIV DNA per cell; this CD32a(+) reservoir was highly enriched in inducible replication-competent proviruses and can be predominant in some participants; that CD32a(+) lymphocytes represent the elusive HIV-1 reservoir may lead to insights that will facilitate the specific targeting and elimination of this reservoir PMID: 28297712
- Single nucleotide polymorphisms (SNPs) rs2099684 in IgG receptors FCGR2A/FCGR3A can be considered a genetic risk factor for Takayasu arteritis (TA) in the Chinese Han population. PMID: 27769046
- The mutant homozygote (CC) of the FCGR2A gene (rs1801274) may have a protective role among Chinese patients with UC. PMID: 27984611
- Review/Meta-analysis: FcgammaRIIa-H131R may modify treatment rituximab response in diffuse large B cell lymphoma. PMID: 28039707
- FCGR2A and FCGR2C polymorphisms may also contribute to immunocomplexemia present in sarcoidosis. PMID: 26801149
- The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo. PMID: 27765766
- FCGR2A expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
- Review/Meta-analysis: Rheumatoid arthritis patients with FCGR2A HH + HR genotype show a poor response to adalimumab. PMID: 27074847
- Our findings indicate that CD16 158F>V polymorphism may contribute to the increased risk of Idiopathic Thrombocytopenic Purpura, whereas CD32 131H>R polymorphism may not be an important risk factor for Idiopathic Thrombocytopenic Purpura. PMID: 27315784
- Our observations support the existence of a central FcgammaRIIA-mediated pathway by which human platelets respond to both Gram-negative and Gram-positive bacteria. PMID: 27025455
- FcgammaRIIA H131 allele and FcgammaRIIA H/H131 genotype were significantly increased in pediatric Guillain-Barre syndrome patients. PMID: 27064330
- FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of Takayasu arteritis. PMID: 26996483
- Data indicate no significant difference in the allele or genotype frequencies of the Fcgamma2RA protein (FCGR2A) rs1801274 single nucleotide polymorphism was observed between groups. PMID: 27267995
- The RR, HR, and HH FCGR2A-131 genotypes were detected in 1 (11 %), 5 (56 %), and 3 (33 %) of patients with disease relapse compared to 25 (21 %), 56 (47 %), and 38 (32 %) of the 119 patients without relapse. PMID: 27376362
- The data indicate that FcgammaRIIA genotyping can be used as a marker of genetic susceptibility to sepsis. PMID: 26490967
- FCGR3A and FCGR2A SNPs do not confer differential responsiveness to rituximab. PMID: 26510856
- Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis. PMID: 26748351
- R/R genotype of FCGR2A p.R131H and G/G genotype of CCL2 c.-2518 A > G polymorphisms are associated with thrombocytopenia, which is a characteristic laboratory finding in dengue infections. PMID: 26429304
- Genetic variants of rs6671847 at FCGR2A and rs17085007 at 13q12 conferred a risk of relapse in patients with ulcerative colitis. PMID: 25787843
- we fail to find the significant association between FCGR2A H131R and clinical outcome in KRAS wild metastatic colorectal cancer individuals with adjuvant cetuximab therapy PMID: 26363448
- The results show an association between FcgRIIa, TNF-alpha and IL-6 gene single nucleotide polymorphisms and symptom persistence in Dengue patients. PMID: 26429310
- FCGR2A polymorphisms constitute a risk factor for graft loss following kidney transplantation and that this effect is related to anti-HLA antibodies. PMID: 26429312
- FcgammaRIIIA/FcgammaRIIA gene polymorphisms and HER-2 may have a role in antibody-dependent cellular cytotoxicity and clinical response to trastuzumab in breast cancer PMID: 26450443
- The goal of the study was the development of a novel method for Y402H (g.43097C>T) genotyping, the confirmation of its association with AMD in the Greek population and the investigation of the H131R polymorphism in AMD PMID: 25811666
- These include an FCGR2A/2C chimeric gene that causes a decreased expression PMID: 26133275
- Genetic variation Fc gamma receptor IIA may contribute to infectious susceptibility in trauma patients. PMID: 26496101
- this meta-analysis suggested that the H131R polymorphism in the FCGR2A gene might be associated with susceptibility to KD in Asians. PMID: 26125827
- study found homozygous carriers of the FcgammaRIIA-131R/R allele had higher malaria-specific antibody levels compared to heterozygous carriers of FcgammaRIIA-131R/H alleles and to homozygous carriers of FcgammaRIIA-131H/H alleles; the pre-existing antibody responses were related to reduced subsequent risk of clinical malaria PMID: 25447268
- Review: discuss role of human FCGR2A in immune processes and thrombosis. PMID: 25900780
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein.
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組織特異性：Found on monocytes, neutrophils and eosinophil platelets.
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