WTAP Antibody, Biotin conjugated
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中文名稱：WTAP兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA618970LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) WTAP Polyclonal antibody
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Uniprot No.：
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基因名：WTAP
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別名：DKFZp686F20131 antibody; Female-lethal(2)D homolog antibody; FL2D_HUMAN antibody; hFL(2)D antibody; KIAA0105 antibody; MGC3925 antibody; Mum2 antibody; OTTHUMP00000017522 antibody; OTTHUMP00000017523 antibody; PNAS 132 antibody; PNAS-132 antibody; PNAS132 antibody; Pre mRNA splicing regulator WTAP antibody; Pre-mRNA-splicing regulator WTAP antibody; Putative pre mRNA splicing regulator female lethal 2D homolog antibody; Putative pre mRNA splicing regulator female lethal(2D) antibody; Putative pre-mRNA splicing regulator female lethal(2D) homolog antibody; putative pre-mRNA splicing regulator female-lethal(2D) antibody; Wilms tumor 1 associated protein antibody; Wilms tumor 1 associating protein antibody; Wilms tumor 1-associating protein antibody; Wilms' tumor 1 associating protein antibody; Wilms' tumour 1-associating protein antibody; WT1 associated protein antibody; WT1-associated protein antibody; WT1-associating protein antibody; wtap antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Pre-mRNA-splicing regulator WTAP protein (1-151AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
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基因功能參考文獻：
- WTAP was over-expressed in glioma tissues, and the expression was closely correlated with glioma grade. PMID: 27370540
- WTAP as a regulatory subunit is required for formation of a functional m6A methyltransferase complex including METTL3 and METTL14, which play an important role in the regulation of gene expression and alternative splicing. PMID: 24407421
- WTAP regulates migration and invasion of cholangiocarcinoma cells. PMID: 23354623
- WTAP has an important role in abnormal proliferation and arrested differentiation of leukemia cells, and WTAP is a novel client protein of Hsp90 PMID: 24413322
- the WTAP complex is a novel component of the RNA processing machinery, implying an important role in both posttranscriptional control and cell cycle regulation. PMID: 24100041
- WTAP overexpression made cancer cells more tumorigenic PMID: 22957919
- WTAP level in poodocytes is a valuable alternative technique in the study of podocyte injury in diabetic nephropathy. PMID: 19969384
- WTAP protein involved in the morphogenesis of the genitourinaty tract and in the etiology of isolated hypospadias. PMID: 14675924
- WTAP and ATF3 Transcription Factor are activated in Wilms' tumor and accelerate tumorigenesis. PMID: 16912181
- WTAP as an essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition PMID: 17088532
- WTAP is a novel regulator of the cell cycle and cell survival and implicate a WTAP-WT1 axis as a novel pathway for controlling vascular smooth muscle cell phenotype. PMID: 17095724
- Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival PMID: 19605357
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亞細胞定位：Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm.
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蛋白家族：Fl(2)d family
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組織特異性：Ubiquitously expressed.
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數據庫鏈接：
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