WBP2 Antibody
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中文名稱：WBP2兔多克隆抗體
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貨號：CSB-PA842628LA01HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA842628LA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) WBP2 Polyclonal antibody
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Uniprot No.：
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基因名：WBP2
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別名：MGC18269 antibody; WBP 2 antibody; WBP-2 antibody; Wbp2 antibody; WBP2_HUMAN antibody; WW domain binding protein 2 antibody; WW domain-binding protein 2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human WW domain-binding protein 2 protein (1-261AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，WBP2 Antibody (CSB-PA842628LA01HU)，的標記方式是Non-conjugated。對于WBP2 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR.
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基因功能參考文獻：
- Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. PMID: 28332498
- WBP2/ITCH signaling functions to link the intricate Wnt and Hippo signaling networks in breast cancer. PMID: 27578003
- the miR-206/WBP2 axis can modulate tamoxifen sensitivity via regulating G1/S progression in estrogen receptor + breast cancer PMID: 28391353
- The authors reported that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse, as well as in two deaf children, each carrying two different variants in the WBP2 gene. PMID: 26881968
- data indicate that WBP-2 enhances ER transactivation function at certain genes by facilitating the recruitment and/or the stabilization of a histone modifier enzyme that favors a relaxed chromatin structure, permissive of transcription PMID: 23233354
- The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP2 and WBP1 in a highly promiscuous and subtle manner. PMID: 21981024
- Data show that direct interaction of Wbp2 with TAZ depends on the WW domain of TAZ. PMID: 20972459
- WW domain binding protein-2, an E6-associated protein interacting protein, acts together with YAP as coactivators of estrogen and progesterone receptors. PMID: 16772533
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相關疾病：Deafness, autosomal recessive, 107 (DFNB107)
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亞細胞定位：Cytoplasm. Nucleus.
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組織特異性：Ubiquitous.
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數據庫鏈接：
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