WBP2 Antibody, Biotin conjugated

說明書

中文名稱：

WBP2兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA842628LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) WBP2 Polyclonal antibody
Uniprot No.：

Q969T9
基因名：

WBP2
別名：

MGC18269 antibody; WBP 2 antibody; WBP-2 antibody; Wbp2 antibody; WBP2_HUMAN antibody; WW domain binding protein 2 antibody; WW domain-binding protein 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human WW domain-binding protein 2 protein (1-261AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR.
基因功能參考文獻：
1. Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. PMID: 28332498
2. WBP2/ITCH signaling functions to link the intricate Wnt and Hippo signaling networks in breast cancer. PMID: 27578003
3. the miR-206/WBP2 axis can modulate tamoxifen sensitivity via regulating G1/S progression in estrogen receptor + breast cancer PMID: 28391353
4. The authors reported that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse, as well as in two deaf children, each carrying two different variants in the WBP2 gene. PMID: 26881968
5. data indicate that WBP-2 enhances ER transactivation function at certain genes by facilitating the recruitment and/or the stabilization of a histone modifier enzyme that favors a relaxed chromatin structure, permissive of transcription PMID: 23233354
6. The WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP2 and WBP1 in a highly promiscuous and subtle manner. PMID: 21981024
7. Data show that direct interaction of Wbp2 with TAZ depends on the WW domain of TAZ. PMID: 20972459
8. WW domain binding protein-2, an E6-associated protein interacting protein, acts together with YAP as coactivators of estrogen and progesterone receptors. PMID: 16772533
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相關疾病：

Deafness, autosomal recessive, 107 (DFNB107)
亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 12738

OMIM: 606962

KEGG: hsa:23558

STRING: 9606.ENSP00000254806

UniGene: Hs.514489

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