WAC Antibody

說(shuō)明書

中文名稱：

WAC兔多克隆抗體
貨號(hào)：

CSB-PA861133HA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA861133HA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA861133HA01HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA861133HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) WAC Polyclonal antibody
Uniprot No.：

Q9BTA9
基因名：

WAC
別名：

1110067P07Rik antibody; BA48B24 antibody; BA48B24.1 antibody; BM 016 antibody; FLJ31290 antibody; KIAA1844 antibody; MGC10753 antibody; OTTHUMP00000019380 antibody; OTTHUMP00000019382 antibody; PRO1741 antibody; wac antibody; WAC_HUMAN antibody; WW domain containing adapter protein with coiled coil antibody; WW domain containing adaptor with coiled coil antibody; WW domain-containing adapter protein with coiled-coil antibody; Wwp4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，WAC Antibody (CSB-PA861133HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于WAC Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA861133HB01HU	WAC Antibody, HRP conjugated	ELISA
FITC	CSB-PA861133HC01HU	WAC Antibody, FITC conjugated
Biotin	CSB-PA861133HD01HU	WAC Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.
基因功能參考文獻(xiàn)：
1. Our observation allows us to redefine the smallest region of overlap among patients reported so far, with a size of 80 Kb and which contains only the WAC gene. These findings strengthen the hypothesis that haploinsufficency of WAC gene might be likely responsible for intellectual disability and behavior disorders. PMID: 27119754
2. De novo WAC loss-of-function mutations were identified through exome sequencing of individuals with unexplained intellectual disability. PMID: 26757981
3. WAC loss-of-function mutations cause a recognisable syndrome characterised by dysmorphic features, developmental delay and hypotonia and recapitulate 10p11.23 microdeletion syndrome PMID: 26264232
4. The identification of SCOC and WAC as novel regulatory proteins with diverse functions in autophagy contributes towards a fuller understanding of autophagosome formation. PMID: 22354037
相關(guān)疾病：

DeSanto-Shinawi syndrome (DESSH)
亞細(xì)胞定位：

Nucleus speckle. Nucleus.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 17327

OMIM: 615049

KEGG: hsa:51322

STRING: 9606.ENSP00000346986

UniGene: Hs.743224

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