VSIR Antibody

中文名稱：

VSIR兔多克隆抗體
貨號：

CSB-PA884484LA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: C10orf54 antibody at 4μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA884484LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) VSIR Polyclonal antibody
Uniprot No.：

Q9H7M9
基因名：

VSIR
別名：

B7 H5 antibody; B7H5 antibody; C10orf54 antibody; chromosome 10 open reading frame 54 antibody; DD1alpha antibody; GI24 antibody; GI24_HUMAN antibody; PD-1H antibody; PDCD1 homolog antibody; Platelet receptor Gi24 antibody; PP2135 antibody; sisp 1 antibody; SISP1 antibody; stress induced secreted protein 1 antibody; UNQ730/PRO1412 antibody; V domain Ig suppressor of T cell activation antibody; V set domain containing immunoregulatory receptor antibody; V set immunoregulatory receptor antibody; V type immunoglobulin domain containing suppressor of T cell activation antibody; VISTA antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human V-type immunoglobulin domain-containing suppressor of T-cell activation protein (37-194AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，VSIR Antibody (CSB-PA884484LA01HU)，的標記方式是Non-conjugated。對于VSIR Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA884484LB01HU	VSIR Antibody, HRP conjugated	ELISA
FITC	CSB-PA884484LC01HU	VSIR Antibody, FITC conjugated
Biotin	CSB-PA884484LD01HU	VSIR Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.
基因功能參考文獻：
1. Data indicate that VISTA is predominantly expressed and up-regulated in the high-density infiltrated immune cells but minimal in pancreatic cancerous cells. PMID: 29771768
2. High VISTA expression is associated with colorectal carcinoma. PMID: 30128738
3. VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID: 29216931
4. This study is the first to describe the expression of VISTA-expressing lymphocytes in melanoma samples and in the context of acquired resistance to immune checkpoint inhibitors PMID: 28776578
5. Taken together, the results indicated that the VISTA high and CD8 low group, as an immunosuppressive subgroup, might be associated with a poor prognosis in primary OSCC. These findings indicated that VISTA might be a potential immunotherapeutic target in OSCC treatment. PMID: 28236118
6. this review describes the functions of VISTA in the context of cancer immunotherapy PMID: 28258694
7. overexpression of the newly described co-stimulatory molecule, PD1 homologue (PD-1H) in human monocyte/macrophages is sufficient to induce spontaneous secretion of multiple cytokines. PMID: 25279955
8. p53-induced expression of DD1alpha prevents persistence of cell corpses and ensures efficient generation of precise immune responses in mice. PMID: 26228159
9. Results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP. PMID: 20666777
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
組織特異性：

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta
數(shù)據(jù)庫鏈接：

HGNC: 30085

OMIM: 615608

KEGG: hsa:64115

STRING: 9606.ENSP00000378409

UniGene: Hs.47382

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