VPS26B Antibody, HRP conjugated

說明書

中文名稱：

VPS26B兔多克隆抗體, HRP偶聯
貨號：

CSB-PA676824LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) VPS26B Polyclonal antibody
Uniprot No.：

Q4G0F5
基因名：

VPS26B
別名：

Pep8b antibody; Vacuolar protein sorting 26 homolog B (S. pombe) antibody; Vacuolar protein sorting 26 homolog B (yeast) antibody; Vacuolar protein sorting-associated protein 26B antibody; Vesicle protein sorting 26B antibody; VP26B_HUMAN antibody; VPS26B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Vacuolar protein sorting-associated protein 26B protein (1-336AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1.
基因功能參考文獻：
1. Authors propose that PAR-2 plasma membrane repopulation is regulated by Vps26B-retromer, describing a potential novel role for this complex. PMID: 26113136
2. Colocalization of Vps26 paralogues with different endosomally located Rab proteins shows prolonged association of Vps26B-retromer with maturing endosomes relative to Vps26A-retromer. PMID: 21920005
亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Late endosome.
蛋白家族：

VPS26 family
數據庫鏈接：

HGNC: 28119

OMIM: 610027

KEGG: hsa:112936

STRING: 9606.ENSP00000281187

UniGene: Hs.334684

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