USP9X Antibody, FITC conjugated
-
中文名稱(chēng)：USP9X兔多克隆抗體, FITC偶聯(lián)
-
貨號(hào)：CSB-PA856610LC01HU
-
規(guī)格：￥880
-
其他：
產(chǎn)品詳情
-
產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) USP9X Polyclonal antibody
-
Uniprot No.：
-
基因名：
-
別名：Deubiquitinating enzyme FAF X antibody; Deubiquitinating enzyme FAF-X antibody; DFFRX antibody; Drosophila fat facets related X linked antibody; FAF antibody; Fafl antibody; Fam antibody; Fat facets homolog antibody; Fat facets in mammals antibody; Fat facets protein related X linked antibody; Fat facets protein related, X-linked antibody; Fat facets protein-related antibody; hFAM antibody; MRX99 antibody; Probable ubiquitin carboxyl terminal hydrolase FAF X antibody; Probable ubiquitin carboxyl-terminal hydrolase FAF-X antibody; Ubiquitin carboxyl-terminal hydrolase FAM antibody; Ubiquitin specific peptidase 9 X linked antibody; Ubiquitin specific peptidase 9, X-linked antibody; Ubiquitin specific processing protease FAF X antibody; Ubiquitin specific protease 9 X chromosome antibody; Ubiquitin thioesterase FAF X antibody; Ubiquitin thiolesterase FAF X antibody; Ubiquitin thiolesterase FAF-X antibody; Ubiquitin-specific protease 9 antibody; Ubiquitin-specific-processing protease FAF-X antibody; USP9 (gene name) antibody; Usp9x antibody; USP9X_HUMAN antibody; Uubiquitin specific protease 9, X chromosome (fat facets like Drosophila) antibody; X chromosome antibody; X-linked antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human
-
免疫原：Recombinant Human Probable ubiquitin carboxyl-terminal hydrolase FAF-X protein (2360-2484AA)
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：FITC
-
克隆類(lèi)型：Polyclonal
-
抗體亞型：IgG
-
純化方式：>95%, Protein G purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
-
儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration. Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity.
-
基因功能參考文獻(xiàn)：
- USP9X is overexpressed in breast carcinomas, and its level of expression is correlated with that of CEP131. USP9X is an important regulator of centrosome biogenesis and USP9X/CEP131 plays a critical role in breast carcinogenesis. PMID: 28361952
- High USP9X expression is associated with Pancreatic Ductal Adenocarcinoma. PMID: 29248719
- USP9X is a deubiquitylase of the Hippo pathway kinase LATS2 and that the Hippo pathway functions as a downstream signaling cascade that mediates USP9X's tumor-suppressive activity. PMID: 29183995
- Ets-1 is induced by BRAF or MEK kinase inhibition, resulting in increased NRAS expression, which could be blocked by inactivation of Usp9x. PMID: 28198367
- LNC473 could recruit deubiquitinase USP9X to inhibit the ubiquitination level of survivin and then increase survivin expression. PMID: 29605299
- Study shows that USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors. USP9X is the first deubiquitylating enzyme shown to stabilize RAPTOR. PMID: 28341829
- Deubiquitylating enzyme USP9X was overexpressed in gastric cancer, suggesting a potential implication as an oncogene, and was significantly associated with a poorer survival. PMID: 28274596
- Study demonstrated that USP9X acts as a tumor metastasis supporter in pancreatic ductal adenocarcinoma (PDAC), and its downregulation inhibited the migration and invasion of PDAC cells, while high expression of USP9X inhibited the apoptosis of cancer cells. Therefore, USP9X functioned as an oncogene in PDAC cells and is closely related with the expression of Snail, Twist and survivin. PMID: 29130109
- knockdown of USP9X was shown to confer resistance to apoptosis following pediatric T-cell acute lymphoblastic leukemia relevant chemotherapy drug treatment in Jurkat leukemia cells PMID: 27602765
- USP9X stabilizes beta-catenin and activates Wnt/beta-catenin signal pathway to promote glioma cell proliferation and survival. PMID: 27783990
- Loss of USP9X expression is associated with pancreatic cancer. PMID: 28720576
- Frame shift mutation in USP9X and deletion of the 5'UTR of the USP9X identified in two females with intellectual disability syndrome. PMID: 28377321
- High USP9X expression is associated with basal-like breast cancer. PMID: 27593927
- The authors find that primary human aggressive B-cell lymphoma samples exhibit high USP9X expression that correlate with XIAP overexpression. PMID: 27317434
- USP9x-SMAD4 Interaction is associated with Breast Cancer Metastasis. PMID: 28115363
- Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein) PMID: 28620049
- USP9X recruited to the centrosome by NPHP5 protects NPHP5 from ubiquitination, thus favouring cilia assembly. PMID: 28498859
- BAG3 was found to positively regulate Mcl-1 levels by binding to and inhibiting USP9X. Our data show that BAG3 and Mcl-1 are key mediators of resistance to chemotherapy in ovarian cancer PMID: 27120977
- found that USP9X regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage PMID: 26921344
- USP9X possibly promotes head and neck cancer cell proliferation through the mTOR pathway. PMID: 27374971
- biological relevance of the ICP0- USP9X complex in HSV-1 infection PMID: 26596467
- identify USP9X as a novel regulator of EGFR endocytosis PMID: 26748853
- study reports for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition PMID: 26598551
- USP9x interacted with and stabilized beta-catenin through deubiquitination to mediate transcription of the decoy receptors in breast cancer cells PMID: 26717875
- We examined the role of USP9X in the primary cilium of affected females with ciliopathy syndromes and found that endogenous USP9X localizes along the length of the ciliary axoneme, so its loss of function could disrupt cilium-regulated processes. PMID: 26833328
- These data support the use of MCL1 expression as a predictive biomarker for USP9X inhibitors in non-small cell lung cancer therapy PMID: 25692226
- The mammalian PRICKLE-interactome was defined, identifying prickle-interacting proteins that localize to synapses and a novel interacting partner, USP9X, a substrate-specific de-ubiquitinase. PRICKLE and USP9X interact through their carboxy-termini; and USP9X de-ubiquitinates PRICKLE, protecting it from proteasomal degradation. PMID: 25763846
- the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice. PMID: 25814533
- Noxa upregulation reduces the availability of Usp9x to Mcl-1, thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells. PMID: 24991768
- Although USP9X may function as a tumor-suppressor during the establishment of PDAC, data presented here argue that USP9X promotes cell growth in advanced PDAC cells when PDAC is typically diagnosed. PMID: 24841553
- Our analysis of clinical HCC samples verifies that miR-26b also targets USP9X expression to inhibit the EMT of hepatocytes PMID: 24890815
- USP9X downregulation renders breast cancer cells resistant to tamoxifen. PMID: 25028367
- USP9X mutations may have a role in X-linked intellectual disability and disrupt neuronal cell migration and growth PMID: 24607389
- a large set of SOX2-associated proteins in DAOY medulloblastoma cells PMID: 23667531
- Mcl-1, Bcl-xL and USP9X overexpression are tumor survival mechanisms protective against chemotherapy. PMID: 23171055
- The resulting USP9X-deficient cancer cells exhibited increased activation of apoptotic pathways. PMID: 22895071
- USP9X is an important regulatory protein of SMURF1. PMID: 23184937
- Usp9x plays an important role in stabilizing SMN and the SMN complex, likely via antagonizing Ub-dependent SMN degradation. PMID: 23112048
- the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR activity and skeletal muscle differentiation. PMID: 22544753
- loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis PMID: 22699621
- Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liver and HeLa cells. PMID: 22371489
- alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination PMID: 22065755
- Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. PMID: 21173155
- Ubiquitin-cycle inhibition represents a novel and effective approach to blocking Bcr-Abl kinase signaling and reducing Mcl-1 levels to engage chronic myelogenous leukemia cell apoptosis. PMID: 21248063
- the deubiquitinase USP9X stabilizes MCL1 and thereby promotes cell survival; deubiquitinases may stabilize labile oncoproteins in human malignancies PMID: 20023629
- FAM associates with E-cadherin and beta-catenin during trafficking to the plasma membrane PMID: 14742711
- identified the ubiquitin-protease FAM/USP9X as a binding partner of Itch. The association between Itch and FAM/USP9X was confirmed in vitro by glutathione S-transferase pulldown and in vivo through coimmunoprecipation PMID: 17038327
- NUAK1 and MARK4 are substrates of USP9X PMID: 18254724
- Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits Smad4 by impeding association with phospho-Smad2; FAM reverts this negative modification, re-empowering Smad4 function. PMID: 19135894
顯示更多
收起更多
-
相關(guān)疾病：Mental retardation, X-linked 99 (MRX99)
-
亞細(xì)胞定位：Cytoplasm. Cell projection, growth cone.
-
蛋白家族：Peptidase C19 family
-
組織特異性：Widely expressed in embryonic and adult tissues.
-
數(shù)據(jù)庫(kù)鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
