UPK3A Antibody
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中文名稱：UPK3A兔多克隆抗體
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貨號：CSB-PA025657ESR2HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA025657ESR2HU at dilution of 1:100 -
Immunofluorescent analysis of HepG2 cells using CSB-PA025657ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) UPK3A Polyclonal antibody
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Uniprot No.：
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基因名：UPK3A
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別名：UPK3A; UPK3; Uroplakin-3a; UP3a; Uroplakin III; UPIII
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Uroplakin-3a protein (19-207AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC, IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
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基因功能參考文獻：
- High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer. PMID: 25743828
- High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder. PMID: 25368291
- a strong association between UPIII and in the group with tumor recurrence PMID: 24553301
- Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer. PMID: 14654529
- Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA]. PMID: 16731295
- uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis PMID: 17698128
- Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells. PMID: 17880289
- Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer PMID: 18313120
- Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma. PMID: 18528285
- Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis. PMID: 19007907
- studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli PMID: 19412341
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相關疾病：Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
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亞細胞定位：Endoplasmic reticulum membrane; Single-pass type I membrane protein.
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蛋白家族：Uroplakin-3 family
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組織特異性：Expressed in ureter.
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數(shù)據庫鏈接：
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