Recombinant Human Uroplakin-3a (UPK3A)

in vitro E.coli expression system

中文名稱：

人UPK3A重組蛋白
貨號(hào)：

CSB-CF025657HU
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

UPK3A
Uniprot No.：

O75631
別名：

UPK3A; UPK3; Uroplakin-3a; UP3a; Uroplakin III; UPIII
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

19-287
氨基酸序列

VNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
基因功能參考文獻(xiàn)：
1. High expression level of preoperative serum Uroplakin III is associated with biologically aggressive bladder cancer. PMID: 25743828
2. High Uroplakin III expression is associated with bladder urothelial carcinoma from malignancy metastatic to the urinary bladder. PMID: 25368291
3. a strong association between UPIII and in the group with tumor recurrence PMID: 24553301
4. Loss of p63 expression is a prerequisite for uroplakin III expression in urothelial bladder cancer. PMID: 14654529
5. Our results indicate that de novo mutations in UPIIIA can be involved in defective early kidney development, but probably constitute only a rare cause of human renal hypodysplasia in a minor subset of individuals [UPIIIA]. PMID: 16731295
6. uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis PMID: 17698128
7. Uroplakin III mRNA is up-regulated to a greater extent in vesicoureteral reflux than in control exfoliated urinary cells. PMID: 17880289
8. Loss of UP III expression is associated with established markers of biologically aggressive bladder cancer PMID: 18313120
9. Not a useful immunohistochemical marker for detection of pleural malignant mesothelioma. PMID: 18528285
10. Uroplakin III plays a pivotal role in Eshcerichia coli UTI pathogenesis. PMID: 19007907
11. studies suggest that bacteria-induced UPIIIa signaling is a critical mediator of bladder responses to insult by uropathogenic E. coli PMID: 19412341
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相關(guān)疾?。?/div>
Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Single-pass type I membrane protein.
蛋白家族：

Uroplakin-3 family
組織特異性：

Expressed in ureter.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 12580

OMIM: 611559

KEGG: hsa:7380

STRING: 9606.ENSP00000216211

UniGene: Hs.632787