TSPEAR Antibody

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TSPEAR Polyclonal antibody
Uniprot No.：

Q8WU66
基因名：

TSPEAR
別名：

Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，TSPEAR Antibody (CSB-PA848817LA01HU)，的標記方式是Non-conjugated。對于TSPEAR Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA848817LB01HU	TSPEAR Antibody, HRP conjugated	ELISA
FITC	CSB-PA848817LC01HU	TSPEAR Antibody, FITC conjugated
Biotin	CSB-PA848817LD01HU	TSPEAR Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.
基因功能參考文獻：
1. TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
2. using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
3. TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
4. TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
5. The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
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相關疾病：

Deafness, autosomal recessive, 98 (DFNB98)
亞細胞定位：

Secreted. Cell surface. Cell projection, stereocilium.
數(shù)據(jù)庫鏈接：

HGNC: 1268

OMIM: 612920

KEGG: hsa:54084

STRING: 9606.ENSP00000321987

UniGene: Hs.660703

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