TMEM132D antibody; HBE120 antibody; KIAA1944 antibody; MOLT antibody; Transmembrane protein 132D antibody; Mature oligodendrocytes transmembrane protein antibody; Mature OL transmembrane protein antibody
宿主:
Rabbit
反應種屬:
Human
免疫原:
Recombinant Human Transmembrane protein 132D protein (796-909AA)
免疫原種屬:
Homo sapiens (Human)
標記方式:
Biotin
克隆類型:
Polyclonal
抗體亞型:
IgG
純化方式:
>95%, Protein G purified
濃度:
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
May serve as a cell-surface marker for oligodendrocyte differentiation.
基因功能參考文獻:
Thus, GPC6 and TMEM132D may serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis. PMID: 26448945
TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotionl signals PMID: 25974322
Enhanced amygdala gray matter volumes and anxiety-related (but not panic-specific) personality profiles are found in healthy normal carriers of the rs11060369 AA TMEM132D genotype. PMID: 24495968
data suggest that not only common but also putatively functional and/or rare variants within TMEM132D might contribute to the risk to develop anxiety disorders PMID: 22911938
TMEM132D was first identified as a possible candidate gene for panic disorder in a genome-wide association study conducted at the Max Planck Institute of Psychiatry in Munich. PMID: 22948381
We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1. PMID: 21784300
TMEM132D may be an important new candidate gene for PD as well as more generally for anxiety-related behavior. PMID: 20368705
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亞細胞定位:
Membrane; Single-pass type I membrane protein.
蛋白家族:
TMEM132 family
組織特異性:
Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis.