TIMM50 Antibody
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中文名稱：TIMM50兔多克隆抗體
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貨號：CSB-PA674736ESR2HU
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規格：￥440
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圖片：
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Western blot
All lanes: TIMM50 antibody at 4.05µg/ml
Lane 1: Rat heart tissue
Lane 2: MM231 whole cell lysate
Lane 3: MCF-7 whole cell lysate
Lane 4: Hela whole cell lysate
Lane 5: 293T whole cell lysate
Lane 6: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40, 51, 28 kDa
Observed band size: 40 kDa -
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA674736ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA674736ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TIMM50 Polyclonal antibody
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Uniprot No.：
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基因名：TIMM50
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別名：TIMM50; TIM50; PRO1512; Mitochondrial import inner membrane translocase subunit TIM50
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宿主：Rabbit
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反應種屬：Human, Rat
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免疫原：Recombinant Human Mitochondrial import inner membrane translocase subunit TIM50 protein (87-353AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.; May participate in the release of snRNPs and SMN from the Cajal body.
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基因功能參考文獻：
- Expression of TIM50 was downregulated in hypertrophic hearts. PMID: 28432072
- Missense mutations in TIMM50 are likely manifesting by severe intellectual disability and epilepsy accompanied by 3-methylglutaconic aciduria and variable mitochondrial complex V deficiency. PMID: 27573165
- TIM50 has a role in regulating cell proliferation and apoptosis through decreasing mitochondrial membrane potential in breast cancer cell PMID: 26289846
- the interaction of divalent metal ions with the intermembrane space domain of Tim50 (Tim50(IMS)) and the interaction of presequence peptides with Tim50(IMS) in presence of Ca(2+) ion was investigated. PMID: 23098911
- The far-UV CD spectra of Tim50(IMS) in native and denatured states revealed that the protein has a significantly folded secondary structure consisted of alpha-helixes and beta-sheets. PMID: 21742040
- Tim50 regulates 3betaHSD2 expression and activity, representing a new role for translocases in steroidogenesis. PMID: 21930695
- TIM50, was upregulated in a non-small cell lung carcinoma cell line (H1299) that expressed the p53 mutants R175H and R273H compared to cells lacking p53. PMID: 21621504
- Tim50 is important for both mitochondrial function and early neuronal development PMID: 15044455
- Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with coilin, snRNPs, and SMN PMID: 16008839
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亞細胞定位：Mitochondrion inner membrane; Single-pass membrane protein.; [Isoform 2]: Nucleus speckle.
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蛋白家族：TIM50 family
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組織特異性：Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).
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數據庫鏈接：
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