TCF7L1 Antibody

中文名稱：

TCF7L1兔多克隆抗體
貨號：

CSB-PA884626OA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: 293 whole cell lysate, U251 whole cell lysate, U87 whole cell lysate
All lanes: TCF7L1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63 kDa
Observed band size: 63 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TCF7L1 Polyclonal antibody
Uniprot No.：

Q9HCS4
基因名：

TCF7L1
別名：

bHLHb21 antibody; HMG box transcription factor 3 antibody; HMG box transcription factor antibody; OTTMUSP00000023419 antibody; T cell factor 3 antibody; TCF 3 antibody; TCF-3 antibody; TCF3 antibody; Tcf7l1 antibody; TF7L1_HUMAN antibody; Transcription factor 7 like 1 (T-cell specific, HMG-box) antibody; Transcription factor 7 like 1 antibody; Transcription factor 7-like 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Peptide sequence from Human Transcription factor 7-like 1 protein (80-99AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TCF7L1 Antibody (CSB-PA884626OA01HU)，的標記方式是Non-conjugated。對于TCF7L1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA884626OB01HU	TCF7L1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA884626OC01HU	TCF7L1 Antibody, FITC conjugated
Biotin	CSB-PA884626OD01HU	TCF7L1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
基因功能參考文獻：
1. HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator. PMID: 21285352
2. Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate. PMID: 23063976
3. Our results identify TCF3 as a central regulator of tumor growth and initiation. PMID: 23090119
4. TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments. PMID: 23492770
5. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
6. These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
7. TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth PMID: 27333864
8. TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation PMID: 29361574
9. Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth. PMID: 28467300
10. report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects PMID: 26764381
11. No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression. PMID: 20532534
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亞細胞定位：

Nucleus.
蛋白家族：

TCF/LEF family
組織特異性：

Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
數據庫鏈接：

HGNC: 11640

OMIM: 604652

KEGG: hsa:83439

STRING: 9606.ENSP00000282111

UniGene: Hs.516297

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