TAF4B Antibody

Name: TAF4B Antibody
Brand: CUSABIO
SKU: CSB-PA849782LA01HU

說(shuō)明書(shū)

中文名稱：

TAF4B兔多克隆抗體
貨號(hào)：

CSB-PA849782LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA849782LA01HU diluted at 1:500 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA849782LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TAF4B Polyclonal antibody
Uniprot No.：

Q92750
基因名：

TAF4B
別名：

TAF4B antibody; TAF2C2 antibody; TAFII105 antibody; Transcription initiation factor TFIID subunit 4B antibody; Transcription initiation factor TFIID 105 kDa subunit antibody; TAF(II)105 antibody; TAFII-105 antibody; TAFII105 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Transcription initiation factor TFIID subunit 4B protein (132-244AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，TAF4B Antibody (CSB-PA849782LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于TAF4B Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA849782LB01HU	TAF4B Antibody, HRP conjugated	ELISA
FITC	CSB-PA849782LC01HU	TAF4B Antibody, FITC conjugated
Biotin	CSB-PA849782LD01HU	TAF4B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
基因功能參考文獻(xiàn)：
1. The existence of a highly conserved TAF4b-dependent gene regulatory network. PMID: 27341508
2. Two candidate loci in each family and homozygous truncating mutations p.R611X in TAF4B in family 1 and p.K507Sfs*3 in ZMYND15 in family 2, were identified. PMID: 24431330
3. We show evidence for the first time of an interdependence of TAF4b and AP-1 family members in cell type-specific promoter recognition and initiation of transcription in the context of cancer progression and EMT. PMID: 20353996
4. histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs PMID: 15601843
5. work suggests that pre-mRNA processing and post-translational modification represent two important regulatory steps for the gonad-specific functions of human TAF(II)105 PMID: 16088961
6. Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC. PMID: 19020761
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相關(guān)疾病：

Spermatogenic failure 13 (SPGF13)
亞細(xì)胞定位：

Nucleus. Cytoplasm.
蛋白家族：

TAF4 family
組織特異性：

Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11538

OMIM: 601689

KEGG: hsa:6875

STRING: 9606.ENSP00000269142

UniGene: Hs.369519

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