SRY Antibody

說明書

中文名稱：

SRY兔多克隆抗體
貨號：

CSB-PA005928
規(guī)格：

￥1090
圖片：
Western Blot analysis of HeLa cells using SRY Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q05066
基因名：

SRY
別名：

Essential protein for sex determination in human males antibody; Sex determining region on Y antibody; Sex determining region protein antibody; Sex determining region Y antibody; Sex-determining region Y protein antibody; sox21b antibody; SRXX1 antibody; SRXY1 antibody; SRY 1 antibody; SRY antibody; SRY_HUMAN antibody; Sry1 antibody; Sry3BI antibody; SRYGENE antibody; TDF antibody; TDY antibody; Testis determining factor antibody; Testis Determining Factor on Y antibody; Testis-determining factor antibody; Transcription factor Sox-21-B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human SRY.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
基因功能參考文獻：
1. Activation of SRY and its downstream Sox9 and PDGFRalpha pathways are commonly involved in male hepatocarcinogenesis, which provides novel insights into gender disparity and sex-specific therapeutic strategies of hepatocellular carcinoma. PMID: 28942012
2. a single-nucleotide polymorphism in the amelogenin gene using amplified product-length polymorphisms in combination with sex-determining region Y analysis, is reported. PMID: 28052096
3. Missense Mutation 224G>T (R75M) in SRY Coding Region is associated with 46, XY Gonadal Dysgenesis. PMID: 28030592
4. Chemical proteasome inhibition restored native-like SRY expression and transcriptional activity in association with restored occupancy of a sex-specific enhancer element in principal downstream gene Sox9, demonstrating that the variant SRY exhibits essentially native activity on a per molecule basis. PMID: 27576690
5. SRY is involved in the maintenance of cancer stem-like characteristics through OCT4. PMID: 26013162
6. The aim of this study was to compare two Y chromosome markers-SRY and DYS14-for their utility in the diagnosis of fetal gender PMID: 26121024
7. These findings demonstrate that autosomal retention of SRY can be sub-microscopic and emphasize the importance of PCR and FISH in the genetic workup of the monosomic X male PMID: 25374395
8. The SRY gene in plasma extracellular vesicles transferred to vascular endothelial cells may play an important role in the pathogenesis of atherosclerosis PMID: 25783200
9. High levels of SRY expression correlated with cancer progression and poor HCC patient survival. However, high SRY levels are not significantly correlated with HCC sex bias. PMID: 25274159
10. Findings demonstrate that the folding, trafficking, and gene-regulatory function of testis-determining factor SRY requires an invariant aromatic "buttress" beneath its specific DNA-bending surface. PMID: 25258310
11. Data suggest that sex-determining region Y protein SRY upregulation after dopamine cell injury is initially a protective response in males, but diminishes with gradual loss in dopamine cells. PMID: 24708242
12. A proximal promoter construct for the MAS gene was repressed by the SOX [SRY (sex-determining region on the Y chromosome) box] proteins SRY, SOX2, SOX3 and SOX14, of which SRY is known to interact with the KRAB domain. PMID: 24128372
13. Nucleocytoplasmic shuttling of SRY is necessary for robust initiation of testicular development. PMID: 24003159
14. SRY may act as a transcription repressor for pluripotency-associated genes and as a transcription activator for differentiation-related genes in embryonic cells. PMID: 23361361
15. SRY plays a role as a positive regulator of catecholamine synthesis and metabolism in the human male PMID: 22568433
16. A novel SRY mutation leads to asymmetric SOX9 activation and is responsible for mixed 46,XY gonadal dysgenesis. PMID: 22441105
17. 70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY. PMID: 23235156
18. A missense mutation (Glu89Ala) within the SRY HMG-box domain markedly lowers DNA binding activity. PMID: 22288726
19. We found a novel intronic five-SNP haplotype ~730 kb upstream of the type I promoter and determined that this region functions as transcriptional enhancer that is suppressed by SRY. PMID: 22832904
20. Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex. PMID: 21849498
21. A novel SRY missense mutation is identified in two half-sisters and segregates with the CGD phenotype. It is present in the common healthy father in a mosaic state. PMID: 21868002
22. After 28 weeks SRY cell free fetal DNA of male twin pregnancies was significantly increased compared to singleton male pregnancies and mixed-gender twin pregnancies with no differences between the latter two. PMID: 21696822
23. Novel SRY mutations and SF1 (NR5A1) changes in patients with pure gonadal dysgenesis and 46,XY karyotype have been identified. PMID: 21242195
24. The study found two ribosomal proteins, RPS7 and RPL13A that interact with the HMG (high-mobility group) box domain of SRY. PMID: 21114473
25. Findings indicate that mutations in SRY are rare in patients with Y chromosome mosaicisms. PMID: 20699606
26. the role of intracellular calcium in modulating SRY nuclear accumulation PMID: 21051653
27. This review examines the role of the SHR Y chromosome and specifically the Sry gene complex in hypertension. PMID: 19914267
28. The expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. PMID: 20347080
29. SRY-deleted XXY may be associated with the development of gonadoblastoma and gonadal dysgenesis. PMID: 20689145
30. SRY has distinct dual nuclear import pathways mediated by the CaM-NLS through CaM and beta-NLS through Impbeta1. Mutation in either NLS can lead to sex reversal. PMID: 20528776
31. analyse the presence of DAZ, RBMY1, USP9Y, protamine-2, SRY and actin messenger RNA (mRNA) in testicular cells of men suffering from idiopathic azoospermia. PMID: 11869379
32. The SRY gene encodes for a protein in the high mobility group that binds to DNA in the nucleus and it regulates the transcription of other genes necessary for testis determination by acting as a repressor or activator of this process. PMID: 11912443
33. Familial mutation in the testis-determining gene SRY shared by an XY female and her normal father. PMID: 12107262
34. presence of hidden mosaicism for SRY or other Y sequences in some patients with XX true hermaphroditism PMID: 12215841
35. analysis of missense mutations in SRY site reveals its role in gonadal dysgenesis PMID: 12483463
36. Sry and the genetics of sex determination. Review. PMID: 12575752
37. Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. PMID: 12764225
38. 2 new mutations of SRY were found: R72G ad Q158fX180. PMID: 12919143
39. These results suggest that WT1 forms a complex with SRY to regulate transcription and that this WT1-SRY interaction is important in testis development. PMID: 12970737
40. Results suggest the involvement of SRY gene in sex reversal which further supports the relationship between SRY alterations, gonadal dysgenesis and/or primary infertility. PMID: 15155818
41. acetylation and deacetylation of SRY may be important mechanisms for regulating SRY activity during mammalian sex determination PMID: 15297880
42. Results show that fetal SRY gene can be found at a time as early as 42 days of gestation in maternal plasma by the use of FQ-PCR. PMID: 15300641
43. We confirmed previous reports that mutations in the SRY gene are not associated with anorchia. Lack of association between genetic factors necessary for correct testicular descent and anorchia. PMID: 15579790
44. SRY nuclear import during gonadal development and disruption directly depends on calmodulin. PMID: 15746192
45. Human SRY 5' flanking sequences supported reporter transgene expression within the genital ridge of male embryos at the time of sex determination and also supported expression within migrating truncal neural crest cells of both male and female embryos. PMID: 16411204
46. SRY tail functions as a "kinetic clamp" to regulate the lifetime of the bent DNA complex. PMID: 16504207
47. The human Y chromosome is affected by high levels of natural background radiation and can harbor copy number polymorphisms that cause sex chromosome related anomalies. PMID: 16510537
48. Male development is robust to subtle alterations in SRY-DNA architecture but depends critically on nuclear localization. PMID: 16762365
49. The AZFc variation was detected in five cases of male infertility. PMID: 17762975
50. A case of SRY(-) 46,XX monozygotic twins with genital ambiguity is reported. PMID: 18056774
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相關疾病：

46,XY sex reversal 1 (SRXY1); 46,XX sex reversal 1 (SRXX1)
亞細胞定位：

Nucleus speckle. Cytoplasm. Nucleus.
蛋白家族：

SRY family
數(shù)據(jù)庫鏈接：

HGNC: 11311

OMIM: 400044

KEGG: hsa:6736

STRING: 9606.ENSP00000372547

UniGene: Hs.1992

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