SRSF6 Antibody

說明書

中文名稱：

SRSF6兔多克隆抗體
貨號：

CSB-PA050023
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q13247
基因名：

SRSF6
別名：

arginine/serine-rich 6 antibody; B52 antibody; Epididymis secretory protein Li 91 antibody; fc17h09 antibody; HEL S 91 antibody; MGC128807 antibody; MGC5045 antibody; Pre mRNA splicing factor SRP55 antibody; Pre-mRNA-splicing factor SRP55 antibody; Serine/arginine-rich splicing factor 6 antibody; SFRS6 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 55 kDa antibody; Splicing factor arginine/serine rich 6 antibody; SR splicing factor 6 antibody; SRP55 antibody; SRSF6 antibody; SRSF6_HUMAN antibody; wu:faa54g02 antibody; wu:fc17h09 antibody; zgc:103497 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human SRp55.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
基因功能參考文獻：
1. Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator SRP55; SRP55-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX), JNK signaling, and endoplasmic reticulum stress. (BIM = BCL-2 interacting protein BIM; BAX = apoptosis regulator BAX) PMID: 29246973
2. The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease. PMID: 27529534
3. LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic. PMID: 27443606
4. SRSF6 is a regulator of wound healing and tissue homeostasis in skin. PMID: 24440982
5. Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS. PMID: 23648111
6. The splicing factor SRSF6 is an oncoprotein that regulates the proliferation and survival of lung and colon cancer cells. PMID: 23132731
7. Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. PMID: 22767602
8. Report upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors. PMID: 22516966
9. SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs. PMID: 21345357
10. interacts with calcitonin/CGRP exon 4 exonic splice enhancer(ESE); binding of SRp55 to an ESE required for calcitonin mRNA splicing suggests that the different levels of SRp55 in different cell types may regulate calcitonin/CGRP alternative splicing PMID: 12531473
11. SRp55 binding to a suboptimal RNA binding site in the calcitonin/CGRP pre-mRNA exonic splice enhancer, or increasing the amount of SRp55 in cells, is required for calcitonin mRNA production. PMID: 12549914
12. Higher relative expression of SR55 protein in breast tumors was associated with altered pattern of CD44 variants incorporating exon v7 PMID: 12779084
13. These findings show that modulation of splicing activity in p53-deficient cells during the early response to sub-lethal DNA damage results in a change in the splicing of target genes, thus modifying the cellular response to genotoxic agents. PMID: 18571879
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亞細胞定位：

Nucleus. Nucleus speckle.
蛋白家族：

Splicing factor SR family
數(shù)據(jù)庫鏈接：

HGNC: 10788

OMIM: 601944

KEGG: hsa:6431

STRING: 9606.ENSP00000244020

UniGene: Hs.684950

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