SRSF10 Antibody

中文名稱：

SRSF10兔多克隆抗體
貨號：

CSB-PA525638LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA525638LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SRSF10 Polyclonal antibody
Uniprot No.：

O75494
基因名：

SRSF10
別名：

40 kDa SR repressor protein antibody; 40 kDa SR-repressor protein antibody; Anti TLS associated protein with SR repeats antibody; arginine/serine-rich 13A antibody; FUS interacting protein serine arginine rich 1 antibody; FUS interacting protein serine arginine rich 2 antibody; FUS interacting serine arginine rich protein 1 antibody; FUS-interacting serine-arginine-rich protein 1 antibody; FUSIP1 antibody; FUSIP2 antibody; NSSR antibody; OTTHUMP00000015774 antibody; Serine arginine repressor protein 40 kDa antibody; Serine/arginine-rich splicing factor 10 antibody; SFRS13 antibody; SFRS13A antibody; Splicing factor antibody; Splicing factor arginine serine rich 13 antibody; Splicing factor SRp38 antibody; SRp38 antibody; SRp40 antibody; SRrp40 antibody; SRS10_HUMAN antibody; Srsf10 antibody; TASR antibody; TASR1 antibody; TASR2 antibody; TLS associated protein TASR1 antibody; TLS associated protein TASR2 antibody; TLS associated protein with Ser Arg repeats antibody; TLS associated protein with SR repeats antibody; TLS associated serine arginine protein 1 antibody; TLS associated serine arginine protein 2 antibody; TLS associated serine arginine protein antibody; TLS associated SR protein antibody; TLS-associated protein with Ser-Arg repeats antibody; TLS-associated protein with SR repeats antibody; TLS-associated serine-arginine protein antibody; TLS-associated SR protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/arginine-rich splicing factor 10 protein (1-183AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，SRSF10 Antibody (CSB-PA525638LA01HU)，的標記方式是Non-conjugated。對于SRSF10 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA525638LB01HU	SRSF10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA525638LC01HU	SRSF10 Antibody, FITC conjugated
Biotin	CSB-PA525638LD01HU	SRSF10 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
基因功能參考文獻：
1. DNA damage co-opts SRSF10 to control splicing decisions in transcripts encoding components involved in DNA repair, cell-cycle control, and apoptosis. PMID: 27851963
2. Results show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 while blocking SRSF10 mRNA binding. PMID: 26876937
3. SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells PMID: 25091051
4. In colorectal cancer, NSSR1 was highly expressed in the nucleus of tumor cells. PMID: 21984158
5. Splicing thermotolerance is acquired through maintenance of SRSF10 phosphorylation and that this is mediated at least in part by Hsp27. PMID: 21135127
6. Data show that SFRS13A expression was significantly associated with LDLR splicing efficiency in vivo. PMID: 20232416
7. found to be dephosphorylated specifically in mitotic cells; show that dephosphorylated SRp38 is required for the observed splicing repression PMID: 12419250
8. SRp38 plays a crucial role in cell survival under stress conditions by inhibiting the splicing machinery PMID: 14765198
9. SRp38 contains two arginine- and serine-rich domains (RS), one of which has a unique, second-step repression activity, while both function together as a splicing repression domain. PMID: 16135820
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亞細胞定位：

Nucleus speckle. Cytoplasm.
蛋白家族：

Splicing factor SR family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 16713

OMIM: 605221

KEGG: hsa:10772

STRING: 9606.ENSP00000420195

UniGene: Hs.3530

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