SPPL2B Antibody

中文名稱：

SPPL2B兔多克隆抗體
貨號：

CSB-PA823457LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of A549 cells with CSB-PA823457LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SPPL2B Polyclonal antibody
Uniprot No.：

Q8TCT7
基因名：

SPPL2B
別名：

SPPL2B antibody; IMP4 antibody; KIAA1532 antibody; PSL1 antibody; Signal peptide peptidase-like 2B antibody; SPP-like 2B antibody; SPPL2b antibody; EC 3.4.23.- antibody; Intramembrane protease 4 antibody; IMP-4 antibody; Presenilin homologous protein 4 antibody; PSH4 antibody; Presenilin-like protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SPPL2B Antibody (CSB-PA823457LA01HU)，的標記方式是Non-conjugated。對于SPPL2B Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA823457LB01HU	SPPL2B Antibody, HRP conjugated	ELISA
FITC	CSB-PA823457LC01HU	SPPL2B Antibody, FITC conjugated
Biotin	CSB-PA823457LD01HU	SPPL2B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
基因功能參考文獻：
1. TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b. PMID: 23384347
2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). PMID: 22194595
3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis PMID: 15385547
4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER. PMID: 15998642
5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha into the cytosol. PMID: 16829951
6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment. PMID: 17965014
7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha and caused a relative increase of longer intracellular cleavage products. PMID: 18768471
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.
蛋白家族：

Peptidase A22B family
組織特異性：

Expressed predominantly in adrenal cortex and mammary gland.
數據庫鏈接：

HGNC: 30627

OMIM: 608239

KEGG: hsa:56928

UniGene: Hs.744026

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