SOCS5 Antibody
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中文名稱：SOCS5兔多克隆抗體
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貨號：CSB-PA022394ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022394ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SOCS5 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：SOCS5 antibody; CIS6 antibody; CISH5 antibody; CISH6 antibody; KIAA0671Suppressor of cytokine signaling 5 antibody; SOCS-5 antibody; Cytokine-inducible SH2 protein 6 antibody; CIS-6 antibody; Cytokine-inducible SH2-containing protein 5 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Suppressor of cytokine signaling 5 protein (1-270AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
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基因功能參考文獻：
- These findings indicate that SOCS5 mediates the impaired function of dendritic cells in chronic lymphocytic leukemia patients PMID: 27317770
- Data show that the Japanese encephalitis virus (JEV)-induced expression of miR-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5). PMID: 28196914
- Here the authors show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). PMID: 28195529
- Opisthorchis felineus infection diminishes the risk of atopic bronchial asthma associated with the SOCS5 gene polymorphism. PMID: 25017311
- different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling with JAK1 and SHC-1 PMID: 23990909
- The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model and in dominant model PMID: 24340963
- Exogenous miR-9 effectively reduced SOCS5 levels, leading to activated JAK-STAT pathway, which promoted endothelial cell migration and tumour angiogenesis PMID: 22773185
- Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence. PMID: 22423360
- The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5. PMID: 15590694
- Constitutive expression of SOCS5 in transgenic mice results in reduced eosinophil infiltration in allergic conjunctivitis PMID: 16210657
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