SMPDL3A Antibody, Biotin conjugated

說明書

中文名稱：

SMPDL3A兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA842119LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SMPDL3A Polyclonal antibody
Uniprot No.：

Q92484
基因名：

SMPDL3A
別名：

SMPDL3A antibody; ASML3AAcid sphingomyelinase-like phosphodiesterase 3a antibody; ASM-like phosphodiesterase 3a antibody; EC 3.1.4.- antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a protein (51-350AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity.
基因功能參考文獻：
1. Activation of pregnane X receptor induces SMPDL3A expression in primary hepatocytes. PMID: 28414139
2. Site-specific N-glycosylation is essential for the intracellular stability, secretion and activity of human SMPDL3A. PMID: 28104755
3. Solved the structure of SMPDL3a revealing a calcineurin-like fold. A dimetal site, glycosylation pattern and a disulfide bond network are likely to be conserved also in aSMase. We show that the binuclear site of SMPDL3a is occupied by two Zn(2+) ions. PMID: 26783088
4. Data indicate that sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a nucleotide phosphodiesterase secreted from cholesterol-loaded macrophages. PMID: 25288789
5. the induction of SMPDL3A is liver X receptor-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. PMID: 22810003
6. ASML3a is involved in the process of bladder tumorigenesis PMID: 12442002
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亞細胞定位：

Secreted.
蛋白家族：

Acid sphingomyelinase family
組織特異性：

Detected in blood serum. Detected in macrophages (at protein level).
數據庫鏈接：

HGNC: 17389

OMIM: 610728

KEGG: hsa:10924

STRING: 9606.ENSP00000357425

UniGene: Hs.486357

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