SMAD9 Antibody

說明書

中文名稱：

SMAD9兔多克隆抗體
貨號：

CSB-PA022161
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA022161(SMAD9 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O15198
基因名：

SMAD9
別名：

MAD homolog 9 antibody; Madh6 antibody; Mothers against decapentaplegic antibody; Mothers against decapentaplegic homolog 9 antibody; Mothers against DPP homolog 9 antibody; SMAD 9 antibody; SMAD family member 9 antibody; SMAD, mothers against DPP homolog 9 (Drosophila) antibody; SMAD8A antibody; SMAD8B antibody; Smad9 antibody; SMAD9_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human SMAD9
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
基因功能參考文獻：
1. Our results exclude a significant role for the SMAD9v90m mutation in juvenile polyposis syndrome PMID: 28424237
2. Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension. PMID: 28582316
3. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID: 26748560
4. Case Report: hamartomatous olyposis and gastrointestinal ganglioneuromas with SMAD9 germline mutation that reduces PTEN expression. PMID: 26122142
5. ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad8 PMID: 23384547
6. CREBZF, a novel Smad8-binding protein. PMID: 22707059
7. Study described the first mutation in SMAD8 in a patient with IPAH, and suggested the involvement of SMAD8 in the pathogenesis of PAH. PMID: 19211612
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相關疾病：

Pulmonary hypertension, primary, 2 (PPH2)
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Dwarfin/SMAD family
組織特異性：

Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.
數據庫鏈接：

HGNC: 6774

OMIM: 603295

KEGG: hsa:4093

STRING: 9606.ENSP00000369154

UniGene: Hs.123119

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